REVIEW PAPER
Belimumab – new treatment opportunities in systemic lupus erythematosus
Online publication date: 2012-09-07
Reumatologia 2012;50(4):349-361
KEYWORDS
ABSTRACT
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease which course is characterized by flares and remissions. Despite the progress in its therapy and longer lifespan of patients it still remains a disease of uncertain prognosis and prolonged therapy, including steroid treatment, carries a burden of many side effects. No new treatment have been accepted in SLE for the last 50 years. It has changed lately, as the first biologic treatment – belimumab, monoclonal antibody anty-BLyS – has been registered in SLE. Belimumab inhibits growth factor for B-lymphocytes and in the large clinical trials has proved safe and efficacious in the treatment of SLE. It is especially indicated in patients with active disease, with positive anti-dsDNA antibodies and low complement and dependent on steroids.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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