ORIGINAL PAPER
Growth hormone therapy in growth retardation in juvenile idiopathic arthritis
Online publication date: 2010-05-14
Reumatologia 2010;48(2):112-120
KEYWORDS
ABSTRACT
Growth retardation is a major problem in children suffering from juvenile idiopathic arthritis (JIA), especially those with a systemic and polyarticular course of the disease.
The article reviews the current literature on clinical studies concerned with growth retardation and growth hormone (GH) therapy in children with JIA.
Growth retardation is a result of persistent inflammation in JIA and may be intensified by the adverse effects of glucocorticoid therapy. Current treatment strategies in JIA do not always stop growth retardation, in which case GH therapy is recommended. The best results are achieved when GH is applied before severe growth retardation has appeared.
The article reviews the current literature on clinical studies concerned with growth retardation and growth hormone (GH) therapy in children with JIA.
Growth retardation is a result of persistent inflammation in JIA and may be intensified by the adverse effects of glucocorticoid therapy. Current treatment strategies in JIA do not always stop growth retardation, in which case GH therapy is recommended. The best results are achieved when GH is applied before severe growth retardation has appeared.
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