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ORIGINAL PAPER
Growth hormone therapy in growth retardation in juvenile idiopathic arthritis
Online publication date: 2010-05-14
Reumatologia 2010;48(2):112-120
KEYWORDS
ABSTRACT
Growth retardation is a major problem in children suffering from juvenile idiopathic arthritis (JIA), especially those with a systemic and polyarticular course of the disease.
The article reviews the current literature on clinical studies concerned with growth retardation and growth hormone (GH) therapy in children with JIA.
Growth retardation is a result of persistent inflammation in JIA and may be intensified by the adverse effects of glucocorticoid therapy. Current treatment strategies in JIA do not always stop growth retardation, in which case GH therapy is recommended. The best results are achieved when GH is applied before severe growth retardation has appeared.
The article reviews the current literature on clinical studies concerned with growth retardation and growth hormone (GH) therapy in children with JIA.
Growth retardation is a result of persistent inflammation in JIA and may be intensified by the adverse effects of glucocorticoid therapy. Current treatment strategies in JIA do not always stop growth retardation, in which case GH therapy is recommended. The best results are achieved when GH is applied before severe growth retardation has appeared.
REFERENCES (46)
1.
Petty RE, Southwood TR, Manners P, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton 2001. J Rheumatol 2004; 31: 390-392. .
2.
Szilágyi-Pągowska I. Auksologia – postępy w pediatrii w roku 2001. Medycyna Praktyczna, Pediatria 2002; 2: 127-139. .
3.
Saxena A, Phadke SR, Agarwal SS. Linear catch-up growth. Indian J Pediatr 2000; 67: 225-230. .
4.
Romer T. Hormon wzrostu. W: Leczenie hormonami i pochodnymi hormonów, Pawlikowski M. (red.). Wydawnictwo Lekarskie PZWL, Warszawa 1996; 45-55. .
5.
Pawlaczyk-Wróblewska E, Mrowiska B, Korman E. Ocena zaburzeń wzrastania u dzieci z młodzieńczym przewlekłym zapaleniem stawów. Enokryn Ped 2004; 3: 29-38. .
6.
De Benedetti F, Maghnie M, Martini A. Growth and skeletal maturation. In: Oxford Textbook of Rheumatology, Isenberg DA (ed.). Oxford University Press 2004; 56-60. .
7.
Bacon MC, White PH, Raiten DJ, et al. Nutritional status and growth in juvenile rheumatoid arthritis. Arthritis Rheum 1990; 20: 97-106. .
8.
Gołębiowska M, Brózik H, Chlebna-Sokól D i wsp. Rozwój somatyczny i skład ciała dzieci z młodzieńczym przewlekłym zapaleniem stawów. Reumatologia 1993; 31: 406-420. .
9.
Wang SJ, Yang YH, Lin YT, et al. Attained adult height in juvenile rheumatoid arthritis with or without corticosteroid treatment. Clin Rheumatol 2002; 21: 363-368. .
10.
Garcia-Consuegra MJ, Merino MR, Lama MR, et al. Growth in children with juvenile idiopathic arthritis. Ann Pediatr 2003; 58: 529-37. .
11.
Bartnicka M, Górska A, Urban M. i wsp. Zaburzenia wzrastania w przebiegu młodzieńczego idiopatycznego zapalenia stawów. Endokr Diabetol Chor Przem Mat W Rozw 2007; 13: 116-119. .
12.
Umławska W, Michałowska J, Podwysocka-Harasimowicz M. Ocena poziomu rozwoju fizycznego dzieci i młodzieży z młodzieńczym idiopatycznym zapaleniem stawów. Endokr Diabetol Chor Przem Mat W Rozw 2008; 14: 161-164. .
13.
Simon D, Fernando C, Czernichow P, et al. Linear growth and final height in patients with systemic juvenile idiopathic arthritis treated with longterm glucocorticoids. J Rheumatol 2002; 29: 1296-1300. .
14.
Saha MT, Haapasaari J, Hannula S, et al. Growth hormone is effective in the treatment of severe growth retardation in children with juvenile chronic arthritis. Double blind placebo-controlled followup study. J Rheumatol 2004; 31: 1413-1417. .
15.
Cleary AG, Lancaster GA, Annan F, et al. Nutritional impairment in juvenile idiopathic arthritis. Rheumatology 2004; 42: 1569-1573. .
16.
Bechtold S, Ripperger P, Dalla PR, et al. Growth hormone increases final height in patients with juvenile idiopathic arthritis: Data from a randomized controlles study. J Clin Endocrinol Metab 2007; 92: 3013-3018. .
17.
Simon D, Lucidarme N, Prieur AM, et al. Treatment of growth failure in juvenile chronic arthritis. Horm Res 2002; 58 (suppl 1): 28-32. .
18.
Bechtold S, Roth J. Natural history of growth and body composition in juvenile idiopathic arthritis. Horm Res 2009; 72 (suppl 1): 13-19. .
19.
Shmeling H, Selinger E, Horneff G. Growth reconstitution in juvenile idiopathic arthritis treated with etanercept. Clin Experimen Rheumatol 2003; 21: 779-784. .
20.
MacRae VE, Farquharson C, Ahmed SF. The pathophysiology of the growth plate in juvenile idiopathic arthritis. Rheumatology 2006; 45: 11-19. .
21.
Wong SC, MacRae VE, Gracie JA, et al. Inflammatory cytokines in juvenile idiopathic arthritis: effects on physical growth and the insulin-like-growth factor axis. Growth Horm IGF Res 2008; 18: 369-378. .
22.
Davies O, Jones J, ReeveJ, et al. Juvenile rheumatoid arthritis. Effects of disease activity and recombinant human growth hormone on insulin-like growth factor 1, insulin-like growth factor binding proteins 1 and 3, and osteocalcin. Arthritis Rheum 1997; 40: 332-340. .
23.
Rooney M, Davies UM, Reeve J, et al. Bone mineral content and bone mineral metabolism: changes after growth hormone treatment in juvenile chronic arthritis. J Rheumatol 2000; 27: 1073-1081. .
24.
Liem JJ, Rosenberg AM. Growth patterns in juvenile rheumatoid arthritis. Clin. Exp. Rheumatol 2003; 21: 663-668. .
25.
Al-Mutair A, Bahabri S, Al-Mayouf S, et al. Efficacy of recombinant human growth hormone in children with juvenile rheumatoid arthritis and growth failure. J Pediatr Endocrinol Metab 2000; 13: 899-905. .
26.
Touati G, Prieur AM, Ruiz JC, et al. Beneficial effects of one-year growth hormone administration to children with juvenile chronic arthritis on chronic steroid therapy. I. Effects on growth velocity and body composition J Clin Endocrinol Metab 1998; 83: 403-409. .
27.
Simon D. rhGH treatment in corticosteroid-treated patients. Horm Res 2007 68: 38-45. .
28.
Bechtold S, Ripperger P, Bonfig W, et al. Bone mass development and bone metabolizm in juvenile idiopathic arthritis: treatment with growth hormone for 4 years. J Rheumatol 2004; 31: 1407-1412. .
29.
Butenandt O, Kelch A, Rajmann E. Growth hormone studies in patients with rheumatoid arthritis with or without glucocorticoid therapy. Z Kinderheilkd 1974; 118: 53-62. .
30.
Davies UM, Rooney M, Preece MA, et al. Treatment of growth retardation in juvenile chronic arthritis with recombinant human growth hormone. J Rheumatol 1994; 21: 153-158. .
31.
Petriczko E, Remigolska M, Stępień K, i wsp. Leczenie hormonem wzrostu u czterech pacjentów z ciężkim niedoborem wzrostu w przebiegi przewlekłego zapalenia stawów. Endokrynol Ped 2003; 2 (supl 1): 71. .
32.
Tynjälä P, Lahdenne P, Vähäsalo P. Impact of anti-TNF treatment on growth in severe juvenile idiopathic arthritis. Ann Rheum Dis 2006; 65: 1044-1049. .
33.
Bielecka-Jasiocha J, Rymkiewicz-Kluczyńska B. Psychospołeczne funkcjonowanie dzieci niskorosłych. Endokrynol Ped 2008; 22: 28-33. .
34.
Kwalifikacja do programów leczenia hormonem wzrostu. Załącznik nr 31, Zarządzenie nr 8/2010/DGL Prezesa NFZ z dnia 20.01.2010. .
35.
Krysiak R, Okopie B, Gdula-Dyzo A. Terapia hormonem wzrostu. 2007; 22: 305-321. .
36.
Simon D. Safety of growth hormone treatment in children with juvenile idiopathic arthritis. Horm Res 2009; 72 (suppl 1): 65-68. .
37.
Ward DJ, Hartog M, Ansell BM. Corticosteroid-induced dwarfism in Still's disease treated with human growth hormone. Clinical and metabolic effects including hydroxyproline excretion in two cases. Ann Rheum Dis 1966; 25: 416-421. .
38.
Simon D, Bechtold S. Effects of growth hormone treatment on growth in children with juvenile idiopathic arthritis. Horm Res 2009; 72 (suppl 1): 55-59. .
39.
Bechtold S, Ripperger P, Bonfig W, et al. Growth hormone changes bone geometry and body composition in patients with juvenile idiopathic arthritis requiring glucocorticoid quantitative computed study. J Clin Endocrinol Metab 2005; 90: 3168-3173. .
40.
Bechtold S, Pozza DR, Schwarz HP, et al. Effects of growth hormone treatment in juvenile idiopathic arthritis: bone and body composition. Horm Res 2009; 72 (suppl 1): 60-64. .
41.
Butenandt O. Rheumatoid arthritis and growth retardation in children: treatment with human growth hormone. Eur J Pediatr 1979; 18: 15-28. .
42.
Svantesson H. Treatment of growth failure with human growth hormone in patients with juvenile chronic arthritis. A pilot study. Clin Exp Rheumatol 1991; 9 (suppl 6): 47-50. .
43.
Davies UM, Rooney M, Preece MA, et al. Treatment of growth retardation in juvenile chronic arthritis with recombinant Human growth hormone. J Rheumatol 1994; 21: 153-158 .
44.
Bechtold S, Ripperger P, Häfner R, et al. Growth hormone improves height in patients with juvenile idiopathic arthritis: 4-year data of a controlled study. J Pediatr 2003; 143: 512-519. .
45.
Grote FK, Van Suijlekom-Smit LW, Mul D, et al. Growth hormone treatment in children with rheumatic disease, corticosteroid induced growth retardation and osteopenia. Arch Dis Child 2006; 91: 56-60. .
46.
Simon D, Prieur AM, Quartier P, et al. Early recombinant human growth hormone treatment in glucocorticoid-treated children with Juvenile idiopathic arthritis: a 3- year randomized study. J Clin Endocrinol Metab 2007; 92: 2567-2573.
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