We present two cases of patients with systemic lupus erythematosus (SLE) with renal involvement, who became pregnant in different stages of the disease. The first patient became pregnant after long-term SLE course, with exacerbations of lupus nephritis (LN) and irreversible degenerative changes of hips. However, in the preconception period of SLE, LN remained in remission. There were no signs of SLE exacerbation during pregnancy. The pregnancy was terminated with Caesarean section and delivery of a healthy child. In the second patient, the diagnosis of SLE was established during pregnancy, in an active phase of renal disease, with nephrotic syndrome, which resulted in intensive, immunosuppressive treatment. The delivery of a 480 γ newborn was premature, at 28 weeks gestation. After pregnancy, remission of LN was achieved.