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LETTER TO THE EDITOR
Seronegative polymyalgia rheumatica: an update
1
Internal and Geriatric Medicine Department, Azienda Sanitaria Locale Napoli 3 sud, Sant’Agnello, Naples, Italy
Submission date: 2026-02-10
Acceptance date: 2026-02-24
Online publication date: 2026-03-24
Publication date: 2026-05-09
Corresponding author
Reumatologia 2026;64(2):159-160
TOPICS
REFERENCES (16)
1.
Dasgupta B, Cimmino MA, Kremers HM, et al. 2012 Provisional classification criteria for polymyalgia rheumatica: A European League Against Rheumatism/American College of Rheumatology Collaborative Initiative. Ann Rheum Dis 2012; 71: 484–492, DOI: 10.1136/annrheumdis-2011-200329.
2.
Manzo C, Milchert M. Polymyalgia rheumatica with normal values of both erythrocyte sedimentation rate and C-reactive protein concentration at the time of diagnosis: a four-point guidance. Reumatologia 2018; 56: 1–2, DOI: 10.5114/reum.2018.74740.
3.
Myklebust G, Gran JT. A prospective study of 287 patients with polymyalgia rheumatica and temporal arteritis: clinical and laboratory manifestations at onset of disease and at the time of diagnosis. Br J Rheumatol 1996; 35: 1161–1168, DOI: 10.1093/rheumatology/35.11.1161.
4.
Cantini F, Salvarani C, Olivieri I, et al. Erythrocyte sedimentation rate and C-reactive protein in the evaluation of disease activity and severity in polymyalgia rheumatica: a prospective follow-up study. Semin Arthritis Rheum 2000; 30: 17–24, DOI: 10.1053/sarh.2000.8366.
5.
Owen CE, Martin E, Poon AM, et al. 18f-fdg whole body pet/ct as a diagnostic test for polymyalgia rheumatica in patients with normal inflammatory markers. Ann Rheum Dis 2018; 77 (Suppl 2): 1480, DOI: 10.1136/annrheumdis-2018-eular.5280.
6.
Manzo C, Milchert M, Natale M, Brzosko M. Polymyalgia rheumatica with normal values of both erythrocyte sedimentation rate and C-reactive protein concentration at the time of diagnosis. Rheumatology (Oxford) 2019; 58: 921–923, DOI: 10.1093/rheumatology/key431.
7.
Marsman De, Den Broeder N, Boers N, et al. Polymyalgia rheumatica patients with and without elevated baseline acute phase reactants: distinct subgroups of polymyalgia rheumatica? Clin Exp Rheumatol 2021; 39: 32–37, DOI: 10.55563/ clinexprheumatol/gdps1r.
8.
Kara M, Alp G, Koç AM. Diagnostic difficulties in polymyalgia rheumatica cases with normal erythrocyte sedimentation rate and C-reactive protein values. Medicine 2023; 102: e35385, DOI: 10.1097/MD.0000000000035385.
9.
Manzo C. Polymyalgia rheumatica (PMR) with normal values of both erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration at the time of diagnosis in a centenarian man: a case report. Diseases 2018; 6: 84, DOI: 10.3390/diseases6040084.
10.
Mahgoub AE, Tessema S, Nakhleh R. Normal ESR, CRP and platelet count in giant cell arteritis and polymyalgia rheumatica: a diagnostic conundrum. Eur J Case Rep Intern Med 2022; 9: 003192, DOI: 10.12890/2022_003192.
11.
Schmidt WA. Does polymyalgia rheumatica with normal CRP and ESR exist, and how should it be treated? Z Rheumatol 2025, DOI: 10.1007/s00393-025-01732-x [Article in German].
12.
Falsetti P, Manzo C, Isetta M, et al. Are there definite disease subsets in polymyalgia rheumatica? Suggestions from a narrative review. Healthcare (Basel) 2025; 13: 1226, DOI: 10.3390/healthcare13111226.
13.
Manzo C, Milchert M, Natale M, Brzosko M. Polymyalgia rheumatica without elevated baseline acute phase reactants. Clin Exp Rheumatol 2021; 39: 441, DOI: 10.55563/clinexprheumatol/s4c5k3.
14.
González-Gay MA, García-Porrúa C, Salvarani C, et al. Polymyalgia manifestations in different conditions mimicking polymyalgia rheumatica. Clin Exp Rheumatol 2000; 18: 755–759.
15.
Manzo C, Camellino D. Polymyalgia rheumatica: diagnostic and therapeutic issues of an apparently straightforward disease. Recenti Prog Med 2017; 108: 221–231, DOI: 10.1701/ 2695.27559.
16.
Dejaco C, Singh YP, Perel P, et al. 2015 Recommendations for the management of polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum Dis 2015; 74: 1799–1807, DOI: 10.1136/annrheumdis-2015-207492.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
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