The role of anticentromere antibodies in diagnosis of rheumatic and cancer diseases
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Online publication date: 2012-03-02
Reumatologia 2012;50(1):52-56
Autoantibodies to centromere proteins (CENPs) were first described in 1980 in limited cutaneous SSc (lcSSc) patients. Since that time a number of CENPs have been identified as autoantibody targets in many rheumatic and cancer diseases (Table I, Fig. 1). The general method for detection of anti-centromere antibodies (ACA) is indirect immunofluorescence using HEp-2 cell slides. Autoantibodies CENP-A, -B, -C are relatively specific biomarkers for lcSSc (CREST syndrome). This review focuses on updating information on CENP antibodies against particular autoantigens and their new clinical associations: anti-CENP-A with early Ssc, anti-CENP-D IgM with SLE + Sjögren syndrome, anti-CENP-H (in SSA/SSB negative patients) and anti-CENP-C with Sjögren syndrome. Anti-CENP-F antibodies have totally different clinical significance and occur mainly in cancer diseases.
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