The role of substance P in rheumatoid arthritis
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Online publication date: 2007-10-31
Reumatologia 2007;45(5):290-293
In recent years our knowledge of the role of neuropeptides in the pathogenesis of rheumatic diseases has expanded. Rheumatoid arthritis is a serious inflammatory disease of the distal joints that has a possible neurogenic component underlying its pathology. The author presents an overview of the metabolism and pharmacokinetics of substance P. The neuropeptide substance P is one possible mediator of this interaction, since it can be released into joint tissues from primary sensory nerve fibres. The peptide neurotransmitter substance P is released from the peripheral terminals of nociceptive afferent neurons and can produce physiological changes associated with acute and chronic inflammation.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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