EN PL
CASE REPORT
Acquired haemophilia A in a patient with rheumatoid arthritis
 
More details
Hide details
 
Online publication date: 2011-12-28
 
 
Reumatologia 2011;49(6):446-449
 
KEYWORDS
ABSTRACT
Acquired haemophilia is a rare, life-threatening autoimmune disorder caused by inhibitory autoantibodies directed against various plasma clotting factors. In clinical practice, the most frequently observed are inhibitors of factor VIII – acquired haemophilia A. In about 50% of cases the disease develops in previously healthy subjects, in 35–40% it is secondary to autoimmune disorders, drug reactions or malignancy and in 10–15% it is associated with pregnancy and puerperium. Treatment of acquired haemophilia includes effective bleeding control and elimination of the inhibitor – the ultimate cure for the disease. Authors present a case of a 55-year-old patient with rheumatoid arthritis and acquired haemophilia A (Fig. 1, 2). The manifestations of haemorrhagic diathesis subsided after intravenous application of recombinant activated factor VII, prednisone and cyclophosphamide. The purpose of this report is to increase awareness of the possibility of acquired haemophilia as the reason of bleeding (especially subcutaneous) in patients with rheumatic diseases. Early diagnosis and proper treatment are critical for the disease outcome.
REFERENCES (6)
1.
Collins PW, Percy CL. Advances in the understanding of acquired haemophilia A: implications for clinical practice. Br J Haematol 2010; 148: 183-194.  .
 
2.
Collins PW, Hirsh S, Baglin T, et al. Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors’ Organisation. Blood 2007; 109: 1870-1877.  .
 
3.
Windyga J. Acquired haemophilia. J Transf Med 2010; 4: 131-132.  .
 
4.
Kasper CK, Pool JG. Letter: measurement of mild factor VIII inhibitors in Bethesda units. Thromb Diath Haemorrh 1975; 34: 875-876.  .
 
5.
Sallah S. Treatment of acquired haemophilia with factor eight inhibitor bypassing activity. Haemophilia 2004; 10: 169-173.  .
 
6.
Huth-Kühne A, Baudo F, Collins P, et al. International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. Haematologica 2009; 94: 566-575.
 
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
eISSN:2084-9834
ISSN:0034-6233
Journals System - logo
Scroll to top