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EDITORIAL ARTICLE
Angiogenesis in rheumatoid arthritis
Online publication date: 2011-03-16
Reumatologia 2011;49(1):1-9
KEYWORDS
ABSTRACT
Angiogenesis is the process of formation of new capillary blood vessels that are generated from pre-existing capillaries. Angiogenesis occurs in postnatal life and is regulated by a complex of proangiogenic and antiangiogenic factors (table I). Upregulated angiogenesis accompanies a few pathological conditions. It is indispensable for growth of malignant tumors. Non-neoplastic diseases are also associated with enhanced angiogenesis, including rheumatoid arthritis. Formation of new vessels was revealed in the inflammed synovial membrane, a key phenomenon of rheumatoid arthritis. Disregulation of pro- and anti-angiogenic factors was shown in rheumatoid patients. Drugs known to inhibit synovitis were found to effect (directly or indirectly) intensity of angiogenesis. It is possible that control of angiogenesis may be one of therapeutical mechanisms of pharmacological management of patients with rheumatoid arthritis.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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