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ORIGINAL PAPER
Antibodies against protective molecules in systemic lupus erythematosus
Online publication date: 2010-04-08
Reumatologia 2009;47(6):323-328
KEYWORDS
ABSTRACT
Background: Many experiments in vitro and in vivo show that, in patients with SLE, there is impairment in the clearance of apoptotic cells. This leads to prolonged exposure of autoantigens to the immune system and to autoimmunity.
The aim of the study was to investigate the relationship between antibodies against protective molecules and the activity of lupus measured by the SLEDAI scale.
Material and methods: 45 lupus patients were assessed for the presence of protective molecules in lupus and antibodies against these molecules.
Results: Levels of hsCRP and anti-C1q were higher in SLE patients compared to the control group, whereas the level of MBL was statistically lower in the SLE group. There was no correlation between levels of hsCRP, MBL, C1q, C4, anti-C1q or anti-CRP in patients and the activity of the disease.
Conclusions: CRP plays the most important role in the clearance of apoptotic material in SLE, and therefore is protective in lupus. The lower levels of MBL in patients with SLE suggest its protective value in this disease. There was low incidence of the presence of assessed antibodies, and therefore there was no possibility to evaluate their role in SLE.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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