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REVIEW PAPER
Application of biological agents for treatment of patients with systemic lupus erythematosus
Online publication date: 2011-08-30
Reumatologia 2011;49(4):264-274
KEYWORDS
ABSTRACT
Systemic lupus erythematosus is an autoimmune disorder of unknown aetiology. High efficacy of biological agents in patients with rheumatoid arthritis suggests investigations on similar medication applicable in the management of systemic lupus erythematosus. Several antibodies were investigated including those against soluble B-lymphocyte-stimulating factor, BLyS (B lymphocyte stimulator) (belimubab, briobacept, atacicept), against B cells (rituximab, ocrelizumab, epratuzumab), inhibiting co-stimulation of T cells (abatacept), tolerogens, interferon and others. Despite some beneficial effects, none of the investigated agents is recommended for clinical practice.
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