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2/2014 vol. 52
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REVIEW PAPER
Carbohydrate metabolism disorders in patients with rheumatoid arthritis and ankylosing spondylitis – impact of treatment
Piotr Dąbrowski
,
 
Maria Majdan
 
 
 
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Submission date: 2013-07-28
 
 
Final revision date: 2014-02-13
 
 
Acceptance date: 2014-03-13
 
 
Online publication date: 2014-06-04
 
 
Publication date: 2014-04-30
 
 
Reumatologia 2014;52(2):129-135
DOI: https://doi.org/10.5114/reum.2014.42798
 
 
Article (PDF)
References (45)
 
KEYWORDS
rheumatoid arthritis
carbohydrate metabolism disorders
ankylosing spondylitis
disease-modifying drugs
 
TOPICS
Cytokines, Inflammatory mediators and adaptive immunity in rheumatic diseases
Rheumatoid arthritis- aetiology, pathogenesis, clinical features and treatment
Spondyloarthropaties - aetiology, pathogenesis clinical features and treatment
Diagnostics and imaging in rheumatic diseases
Epidemiology
 
ABSTRACT
Chronic inflammation – the crucial pathogenic mechanism of rheumatoid arthritis and ankylosing spondylitis – is the main cause of accelerated atherosclerosis, insulin resistance and well-known consequences related to it. The conservative treatment of rheumatoid arthritis and ankylosing spondylitis may provide a significant influence on glucose metabolism. The paper is a literature overview concerning insulin resistance and impaired glucose metabolism during treatment with disease-modifying drugs including biologic DMARDs (disease-modifying antirheumatic drugs), corticosteroids and commonly used non-steroidal anti-inflammatory drugs (NSAID). It has been found that the risk of carbohydrate disorders among those patients is much lower after therapy with hydroxychloroquine, methotrexate and TNF blockers – particularly with infliximab. The NSAID may play an important protective role in reducing risk of diabetes. The recent data show, contrary to general opinion, the advantageous outcome for glucose metabolism after treatment with corticosteroids, especially in the early active stage of rheumatoid arthritis.
 
REFERENCES (45)
1.
Peters MJ, van Halm VP, Voskuyl AE, et al. Does rheumatoid arthritis equal diabetes mellitus as independent risk factor for cardiovascular disease? A prospective study. Arthritis Rheum 2009; 61: 1571-1579.  .
Google Scholar
 
 
2.
Simard JF, Mittleman MA. Prevalent rheumatoid arthritis and diabetes among NHANES III participants aged 60 and older. J Rheumatol 2007; 34: 469-473.  .
Google Scholar
 
 
3.
Han C, Robinson DW, Hackett MV, et al. Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. J Rheumatol 2006; 33: 2167-2172.  .
Google Scholar
 
 
4.
Solomon DH, Love TJ, Canning C, Schneeweiss S. Risk of diabetes among patients with rheumatoid arthritis, psoriatic arthritis and psoriasis. Ann Rheum Dis 2010; 69: 2114-2117.  .
Google Scholar
 
 
5.
Maradit-Kremers H, Nicola PJ, Crowson CS, et al. Cardiovascular death in rheumatoid arthritis: a population-based study. Arthritis Rheum 2005; 52: 722-732.  .
Google Scholar
 
 
6.
Fourlanos S, Perry C, Stein MS, et al. A clinical screening tool identifies autoimmune diabetes in adults. Diabetes Care 2006; 29: 970-75.  .
Google Scholar
 
 
7.
Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17: 4-12.  .
Google Scholar
 
 
8.
Hirabara SM, Gorjão R, Vinolo MA, et al. Molecular targets related to inflammation and insulin resistance and potential interventions. J Biomed Biotechnol 2012; 2012: 379024.  .
Google Scholar
 
 
9.
Ferraz Amaro I, Díaz González F, González Juanatey C, González Gay MA. Insulin resistance and rheumatoid arthritis. Rheumatol Clin 2011; 7: 124-129. .
Google Scholar
 
 
10.
Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-336. .
Google Scholar
 
 
11.
Solomon DH, Massarotti E, Garg R, et al. Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis. JAMA 2011; 305: 2525-2531. .
Google Scholar
 
 
12.
Zonana-Nacach A, Santana-Sahagún E, Jiménez-Balderas FJ, Camargo-Coronel A. Prevalence and factors associated with metabolic syndrome in patients with rheumatoid arthritis and systemic lupus erythematosus. J Clin Rheumatol 2008; 14: 74-77. .
Google Scholar
 
 
13.
Toms TE, Panoulas VF, Douglas KM, et al. Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60: more than just an anti-inflammatory effect? A cross sectional study. Arthritis Res Ther 2009; 11: R110. .
Google Scholar
 
 
14.
van Deutekom AW, Nurmohamed MT, Peters MJ, et al. Methotrexate therapy associates with reduced prevalence of the metabolic syndrome in rheumatoid arthritis patients over the age of 60- more than just an anti-inflammatory effect? A cross sectional study. Ann Rheum Dis 2008; 67: 1051-1052. .
Google Scholar
 
 
15.
Quatraro A, Consoli G, Magno M, et al. Hydroxychloroquine in decompensated, treatment-refractory noninsulin-dependent diabetes mellitus. A new job for an old drug? Ann Intern Med 1990; 112: 678-681. .
Google Scholar
 
 
16.
Gerstein HC, Thorpe KE, Taylor DW, Haynes RB. The effectiveness of hydroxychloroquine in patients with type 2 diabetes mellitus who are refractory to sulfonylureas – a randomized trial. Diabetes Res Clin Pract 2002; 55: 209-219. .
Google Scholar
 
 
17.
Wasko MC, Hubert HB, Lingala VB, et al. Hydroxychloroquine and risk of diabetes in patients with rheumatoid arthritis. JAMA 2007; 298: 187-193. .
Google Scholar
 
 
18.
Emami J, Gerstein HC, Pasutto FM, Jamali F. Insulin-sparing effect of hydroxychloroquine in diabetic rats is concentration dependent. Can J Physiol Pharmacol 1999; 77: 118-123. .
Google Scholar
 
 
19.
Mercer E, Rekedal L, Garg R, et al. Hydroxychloroquine improves insulin sensitivity in obese non-diabetic individuals. Arthritis Res Ther 2012; 14: R135. .
Google Scholar
 
 
20.
Rekedal LR, Massarotti E, Garg R, et al. Changes in glycated hemoglobin after initiation of hydroxychloroquine or methotrexate in diabetic patients with rheumatologic diseases. Arthritis Rheum 2010; 62: 3569-3573. .
Google Scholar
 
 
21.
Larsen CM, Faulenbach M, Vaag A, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007; 356: 1517-1526. .
Google Scholar
 
 
22.
Herder C, Brunner EJ, Rathmann W, et al. Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes – the Whitehall II Study. Diabetes Care 2009; 32: 421-423. .
Google Scholar
 
 
23.
Carstensen M, Herder C, Kivimäki M, et al. Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years before diagnosis of type 2 diabetes. Diabetes 2010; 59: 1222-1227. .
Google Scholar
 
 
24.
Huvers FC, Popa C, Netea MG, et al. Improved insulin sensitivity by anti-TNFαlpha antibody treatment in patients with rheumatic diseases. Ann Rheum Dis 2007; 66: 558-559. .
Google Scholar
 
 
25.
Rosenvinge A, Krogh-Madsen R, Baslund B, et al. Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNF-αlpha therapy. Scand J Rheumatol 2007; 36: 91-96. .
Google Scholar
 
 
26.
Kiortsis DN, Mavridis AK, Vasakos S, et al. Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis. Ann Rheum Dis 2005; 64: 765-766. .
Google Scholar
 
 
27.
Gonzales-Gay MA, De Matias JM, Gonzales-Juanatey C, et al. Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis. Clin Exp Rheumatol 2006; 24: 83-86. .
Google Scholar
 
 
28.
Tam LS, Tomlinson B, Chu TT, et al. Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. Clin Rheumatol 2007; 26: 1495-1498. .
Google Scholar
 
 
29.
Oguz FM, Oguz A, Uzunlulu M. The effect of infliximab treatment on insulin resistance in patients with rheumatoid arthritis. Acta Clin Belg 2007; 62: 218-222. .
Google Scholar
 
 
30.
Seriolo B, Paolino S, Ferrone C, et al. Impact of long-term anti-TNF-αlpha treatment on insulin resistance in patients with rheumatoid arthritis. Clin Exp Rheum 2008; 26: 159-160. .
Google Scholar
 
 
31.
Stavropoulos-Kalinoglou A, Metsios GS, Panoulas VF, et al. Anti-tumor necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis. Arthritis Res Ther 2012; 14: R160. .
Google Scholar
 
 
32.
Stagakis I, Bertsias G, Karvounaris S, et al. Anti-tumor necrosis factor therapy improves insulin resistance, beta cell function and insulin signaling in active rheumatoid arthritis patients with high insulin resistance. Arthritis Res Ther 2012; 14: R141. .
Google Scholar
 
 
33.
Ferraz-Amaro I, Arce-Franco M, Muńiz J, et al. Systemic blockade of TNF- does not improve insulin resistance in humans. Horm Metab Res 2011; 43: 801-808. .
Google Scholar
 
 
34.
Van Ralte DH. Diabetogenic effects of glucocorticoid drugs: The known and the unknows. Amsterdam 2012; 300-305. .
Google Scholar
 
 
35.
Gurwitz JH, Bohn RL, Glynn RJ, et al. Glucocorticoids and the risk for initiation of hypoglycemic therapy. Arch Intern Med 1994; 154: 97-101. .
Google Scholar
 
 
36.
Blackburn D, Hux J, Mamdani M, et al. Quantification of the risk of corticosteroid-induced diabetes mellitus among the elderly. J Gen Intern Med 2002; 17: 717-720. .
Google Scholar
 
 
37.
Clore JN, Thurby-Hay L. Glucocorticoid-induced hyperglycemia. Endocr Pract 2009; 15: 469-474. .
Google Scholar
 
 
38.
Dessein PH, Joffe BI, Stanwix AE, et al. Glucocorticoids and insulin sensitivity in rheumatoid arthritis. J Rheumatol 2004; 31: 867-874. .
Google Scholar
 
 
39.
Hällgren R, Berne C. Glucose intolerance in patients with chronic inflammatory diseases is normalized by glucocorticoids. Acta Med Scand 1983; 213: 351-355. .
Google Scholar
 
 
40.
Svenson KL, Lundqvist G, Wide L, Hällgren R. Impaired glucose handling in active rheumatoid arthritis: effects of corticosteroids and antirheumatic treatment. Metab Clin Exp 1987; 36: 944-948. .
Google Scholar
 
 
41.
Hoes JN, van der Goes MC, van Raalte DH, et al. Glucose tolerance, insulin sensitivity and B-cell function with rheumatoid arthritis treated with or without low-to medium dose glucocorticoids. Ann Rheum Dis 2011; 70: 1887-1894. .
Google Scholar
 
 
42.
Den Uyl D, van Raalte DH, Nurmohamed MT, et al. Metabolic effects of high-dose prednisolone treatment in early rheumatoid arthritis: balance between diabetogenic effects and inflammation reduction. Arthritis Rheum 2012; 64: 936-946. .
Google Scholar
 
 
43.
Yang J, Park Y, Zhang H, et al. Feed-forward signaling of TNF-αlpha and NF-kappaB via IKK-beta pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 2009; 296: H1850-H1858. .
Google Scholar
 
 
44.
Hundal RS, Petersen KF, Mayerson AB, et al. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 2002; 109: 1321-1326. .
Google Scholar
 
 
45.
Fleischman A, Shoelson SE, Bernier R, et al. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 2008; 31: 289-294.
Google Scholar
 
 
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