Septic prosthesis loosening is one of the most serious and difficult complications of total joint replacement. Fungal infections after total knee arthroplasty (TKA) are rare. A two-staged procedure (removal of the infected prosthesis with debridement and spacer implantation followed by prosthesis reimplantation) is used most often. We present a case of a woman suffering from rheumatoid arthritis who developed a Candida parapsilosis infection 9 years after TKA. A two-staged procedure was used. Because of still existing signs of infection twice debridement without revision implant removal was performed. Six months of prolonged ketoconazole and fluconazole therapy was used and healing of the infection was achieved. The risk of fungal infection recurrence in this case is high.