Juvenile idiopathic arthritis (JIA) has many clinical manifestations. In several tens of percent of patients with JIA, significant disease activity remains in adulthood, in addition to short stature, physical disability, osteoporosis, dysfunction of internal organs and eyes. Sometimes amyloidosis is a complication of the disease. The individual forms of JIA frequently take the clinical presentation of their equivalents – chronic inflammation of joints, classified in adults. Some undifferentiated forms of JIA still remain undifferentiated. A separate clinical picture during the total disease period in children and adults usually has persistent form of oligoarthritis of JIA with the presence of antinuclear antibodies with or without uveitis. In adults the amount of medications approved for the treatment of chronic arthritis is higher than in children. Strict separation in the records of drug programs for JIA and for arthritis in adults makes it difficult to continue treatment after reaching adulthood.