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6/2011 vol. 49
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REVIEW PAPER
Frequency of occurrence and relationship of known HFE gene mutations with phenotypes of selected rheumatic diseases
Danuta Siedzieniewska-Falkiewicz
,
 
Małgorzata Sochocka-Bykowska
,
 
Elżbieta Konkol-Szymik
,
 
Witold Tłustochowicz
 
 
 
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Online publication date: 2011-12-28
 
 
Reumatologia 2011;49(6):432-438
 
Article (PDF)
References (59)
 
KEYWORDS
haemochromatosis
iron metabolism disorders
rheumatic diseases
 
ABSTRACT
Mutations in genes coding some proteins involved in iron metabolism in men are aetiological factors for diverse forms of hereditary haemochromatosis (HH). Over the last few years the relationship between their occurrence and prevalence and manifestation of diverse rheumatic diseases (mainly osteoarthralgia and rheumatoid arthritis – RA) has been investigated. Until now we have had no answer to the question whether there is a causal relationship between them. In this paper, current knowledge on hereditary haemochromatosis aetiology, and literature review on the relationship of hereditary haemochromatosis prevalence and phenotype of selected rheumatic disorders are briefly presented (Table I).
 
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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