CASE REPORT
Granulomatosis with polyangiitis – diagnostic difficulties?
Submission date: 2014-08-19
Acceptance date: 2014-09-25
Online publication date: 2014-11-17
Publication date: 2014-10-31
Reumatologia 2014;52(5):344-346
KEYWORDS
TOPICS
ABSTRACT
Granulomatosis with polyangiitis (GPA) is characterized by necrotic vasculitis of the medium and small vessels, granuloma formation and presence of antineutrophil cytoplasmic antibodies against proteinase-3 in serum. The upper respiratory tract, lower respiratory tract and kidneys are usually involved in the disease. Atypical clinical presentation may generate problems. In this report we present a case in which the diagnosis of GPA was possible, but was verified during in further clinical observation.
We present the medical history of a 70-year-old woman with ocular symptoms, nasal discharge, progressive hearing impairment, craniofacial inflammatory infiltrates, lymphadenopathy, and microscopic haematuria in laboratory tests. Histopathology did not confirm GPA. cANCA tests were also negative. Finally, after mediastinoscopy and histopathological evaluation of the lymph nodes, the diagnosis of B-cell lymphoma was established.
We present the medical history of a 70-year-old woman with ocular symptoms, nasal discharge, progressive hearing impairment, craniofacial inflammatory infiltrates, lymphadenopathy, and microscopic haematuria in laboratory tests. Histopathology did not confirm GPA. cANCA tests were also negative. Finally, after mediastinoscopy and histopathological evaluation of the lymph nodes, the diagnosis of B-cell lymphoma was established.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
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