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CASE REPORT
HELLP syndrome in a patient with systemic lupus erythematosus and secondary antiphospholipid syndrome
 
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Online publication date: 2011-12-28
 
 
Reumatologia 2011;49(6):456-458
 
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ABSTRACT
The presence of connective tissue diseases is associated with numerous pregnancy complications, such as recurrent miscarriages, intrauterine growth retardation or preeclampsia. A case of a 36-year-old woman with systemic lupus erythematosus and secondary antiphospholipid syndrome who developed a syndrome of haemolysis, elevated liver enzymes and low platelet count (HELLP syndrome) at 17 weeks of gestation is described. Treatment with corticosteroids, subcutaneous heparin, intravenous immunoglobulin and hypotensive drugs led to improvement of the clinical symptoms and normalization of laboratory parameters. Despite treatment, intrauterine foetal death occurred at 18 weeks of gestation. The purpose of this case report is to increase awareness of the possibility of early onset of HELLP syndrome in patients with connective tissue diseases.
 
REFERENCES (16)
1.
Erdemog˘lu M, Kuyumcuog˘lu U, Kale A, et al. Factors affecting maternal and perinatal outcomes in HELLP syndrome: evaluation of 126 cases. Clin Exp Obstet Gynecol 2010; 37: 213-216.  .
 
2.
Kirkpatrick CA. The HELLP syndrome. Acta Clin Belg 2010; 65: 91-97.  .
 
3.
Hupuczi P, Rigo B, Sziller I, et al. Follow-Up Analysis of Pregnancies Complicated by HELLP Syndrome. Fetal Diagn Ther 2006; 21: 519-522.  .
 
4.
Spiegel J, Ishimori ML, Wallace DJ, et al. The lowest surviving birth weight reported in a systemic lupus erythematosus patient: a review of the literature. Lupus 2007; 16: 52-55;  .
 
5.
Thuong D, Tieulie N, Costedoat N, et al. The HELLP syndrome in the antiphospholipid syndrome: retrospective study of 16 cases in 15 women. Ann Rheum Dis 2005; 64;273-278.  .
 
6.
Yucesoy G, Cakiroglu Y, Bodur H, et al. An analysis of HELLP syndrome cases: does platelet count predict adverse maternal and fetal outcomes in women with HELLP syndrome? Arch Gynecol Obstet 2011, 283: 941-945.  .
 
7.
Serrano F, Nogueira I, Borges A, et al. Primary antiphospholipid syndrome: pregnancy outcome in a portuguese population. Acta Reumatol Port 2009; 34: 492-497.  .
 
8.
Wada Y, Sakamaki Y, Kobayashi D, et al. HELLP syndrome, multiple liver infarctions, and intrauterine fetal death in a patient systemic lupus erythematosus and antiphospholipid syndrome. Inter Med 2009; 48: 1555-1558.  .
 
9.
Simetka O, Michalec I, Zewdiová H, et al. Course and delivery outcomes of 34 pregnancies complicated by HELLP syndrom. Ceska Gynekol 2010; 75: 242-247. .
 
10.
Boomsma JM, van Lingen RA, van Eyck J, et al. Short- and long-term outcome of infants born after maternal (pre)-eclampsia, HELLP syndrome and thrombophilia: a retrospective, cohort study. Eur J Obstet Gynecol Reprod Biol 2010; 153: 47-51. .
 
11.
Merz WM, Gembruch U. Severe, early-onset hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome episode with spontaneous remission during pregnancy. J Matern Fetal Neonatal Med 2007; 20: 631-632. .
 
12.
Stella CL, Sibai BM. Preeclampsia: Diagnosis and management of the atypical presentation. J Matern Fetal Neonatal Med 2006; 19: 381-386. .
 
13.
Yildirim G, Gungorduk K, Gul A, et al. HELLP Syndrome: 8 Years of Experience from a Tertiary Referral Center in Western Turkey. Hypertens Pregnancy 2010 Sep 7. [Epub ahead of print]. .
 
14.
Wang YQ, Wang J, Ye RH, et al. Investigation of diagnosis and treatment of hemolysis-elevated liver enzymes-low platelet counts (HELLP) syndrome: clinical analysis of 59 cases. Chin Med J (Engl) 2010; 123: 1273-1277. .
 
15.
Gasem T, Al Jama FE, Burshaid S, et al. Maternal and fetal outcome of pregnancy complicated by HELLP syndrome. J Matern Fetal Neonatal Med 2009; 22: 1140-1143. .
 
16.
Woudstra DM, Chandra S, Hofmeyr GJ, et al. Corticosteroids for HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome in pregnancy. Cochrane Database Syst Rev 2010; (9): CD008148.
 
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