Nowe przesłanki o roli szpiku kostnego w patogenezie reumatoidalnego zapalenia stawów.
Data nadesłania: 19-09-2016
Data akceptacji: 03-10-2016
Data publikacji online: 28-11-2016
Data publikacji: 28-10-2016
Reumatologia 2016;54(5):215-216
A growing body of evidence indicate that bone marrow participates in the pathogenesis of rheumatoid arthritis (RA). We and others have shown that in bone marrow of RA patients inflammatory response can develop. In addition, pathological events in bone marrow may even precede the signs of synovitis. Furthermore, the association of bone marrow lesions in RA with more erosive disease was found. Published few months ago two reports provided some evidences that support concept of a key role of bone marrow in ACPA-positive RA as a site where bone destruction can be initiated. These new data identify also ACPA as osteoclastogenesis promoting factor. The results of recent studies may thus bring us closer to the understanding of mechanisms triggering pathological events in RA and suggest new potential targets for therapeutic and preventive interventions interfering with osteoclasts activity.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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