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REVIEW PAPER
New trends in pharmacotherapy of lumbar spine pain syndromes
Online publication date: 2010-11-16
Reumatologia 2010;48(5):345-348
KEYWORDS
ABSTRACT
Current opinions about radicular pathology and origin of pain in degenerative disc disease are presented. Increasingly, many authors point to the inflammatory process in pathophysiology of morphological and functional nerve root changes and radicular pain origin. Now it is clear that the nucleus pulposus has antigenic properties and may be a source of many inflammatory mediators, particularly TNFα. Observations from the first clinical investigations including biological therapy of radicular pain and root dysfunction in disc disease are favourable, but too limited. Therefore many more clinical multicentre, randomized trials are needed, to answer in depth the question about the effectiveness and usefulness of biological drugs in routine clinical therapy of radicular pain syndrome
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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