REVIEW PAPER
Metalloproteinases in the pathogenesis of systemic inflammatory rheumatic diseases
Metalloproteinases in the pathogenesis of systemic inflammatory rheumatic diseases
Online publication date: 2005-10-27
Reumatologia 2005;43(5):280-285
KEYWORDS
ABSTRACT
Metalloproteinases (MMPs) are a family of enzymes that hydrolyze components of the extracellular matrix. These proteinases play a key role in the majority of biological processes, both physiological, such as embryogenesis, wound healing, angiogenesis, and pathological, like for example rheumatic diseases. The increasing number of evidence concerning the role of metalloproteinases in inflammatory rheumatic diseases shows not only the direction of future researches, but also gives new targets for the therapies of these so far incurable diseases.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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