Sarcoidosis is a systemic disorder of unknown origin. It is characterized by a noncaseating granulomatous. Many organs can be affected, but the most frequently lungs (almost 90% cases of sarcoidosis). The other organs: lymph nodes, liver, skin and eyes are often involved too. 5% cases of sarcoidosis can be acute with hilar adenopathy, erythema nodosum, fever and articular manifestation and it is called Löfgren’s syndrome. The most common symptoms and signs of sarcoidosis are: fatigue, malaise, cough, shortness of breath and chest pain. Almost 92% patients have abnormal chest roentgenograms. In based on this roentgenograms are distinguished four stages of disease. The treatment in sarcoidosis is difficult and depends on manifestation of disease. Adrenal costicosteroides are commonly used in ocular, neurologic or cardiac sarcoidosis, malignant hypercalcemia and II, III pulmonary stage disease. Recently variety of other pharmacologic approches has been proposed, for example methotrexate, cyclosporine, hydroxychloroquine, quinolones. Prognosis in sarcoidosis depends on stage of disease. The best prognosis have patients with I stage sarcoidosis and with Löfgren’s syndrome.