Rheumatic manifestations in hepatitis C virus infection. Case reports
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Online publication date: 2013-03-05
Reumatologia 2013;51(1):96-99
Apart from hepatic symptoms, many manifestations of autoimmune disorders such as cryoglobulinemic vasculitis, Sjögren’s syndrome (SS), systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) may be present in the course of hepatitis C virus (HCV) infection. The aim of the study was to analyze three cases with rheumatic manifestations in HCV infection. Case 1: a 59-year-old woman with chronic hepatitis C, first diagnosed with RA, later with SLE; also manifestations of SS syndrome and cryoglobulinemic vasculitis were observed. Case 2: a 46-year-old woman with chronic hepatitis C and SS. Case 3: a 33-year-old woman with chronic hepatitis C and SLE.
Palazzi C, Buskila D, D’Angelo S, et al. Autoantibodies in patients with chronic hepatitis C virus infection: pitfalls for the diagnosis of rheumatic diseases. Autoimmun Rev 2012; 11: 659-663.
Antonelli A, Ferri C, Galeazzi M, et al. HCV infection: pathogenesis, clinical manifestations and therapy. Clin Exp Rheumatol 2008; 26: 39-47.
Sansonno L, Tucci FA, Sansonno S, et al. B cells and HCV: an infection model of autoimmunity. Autoimmun Rev 2009; 9: 93-94.
Böckle BC, Baltaci M, Ratzinger G, et al. Hepatitis C and autoimmunity: a therapeutic challenge. J Intern Med 2012; 271: 104-106.
Lormeau C, Falgarone G, Roulot D, et al. Rheumatologic manifestations of chronic hepatitis C infection. Joint Bone Spine 2006; 73: 633-638. .
Pietrogrande M, De Vita S, Zignego AL, et al. Recommendations for the management of mixed cryoglobulinemia syndrome in hepatitis C virus-infected patients. Autoimmun Rev 2011; 10: 444-454.
Ramos-Casals M, Jara L, Medina F, et al. Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): patterns of clinical and immunological expression in 180 cases. J Intern Med 2005; 257: 549-557.
Sene D, Ghillani-Dalbin P, Thibault V, et al. Long-term course of mixed cryoglobulinemia in patients infected with hepatitis C virus. J Rheumatol 2004; 31: 2199-2206.
Haddad J, Deny P, Munz-Gotheil C, et al. Lymphocyti C sialadenitis of Sjögren’s syndrome associated with chronic hepatitis C virus liver disease. Lancet 1992; 339: 321-323.
Pawlotsky JM, Ben Yahia M, Andre C, et al. Immunological disorders in C virus chronic active hepatitis: a prospective case-control study. Hepatology 1994; 19: 841-848.
Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Is hepatitis C virus a sialotropic virus? Am J Pathol 2001; 159: 1593-1594.
Nagao Y, Hanada S, Shishido S, et al. Incidence of Sjögren’s syndrome In Japanese patients with hepatitis C virus infection. J Gastroenterol Hepatol 2003; 18: 258-266.
Ramos-Casals M, Loustaud-Ratti V, De Vita S, et al. SS-HCV Study Group. Sjögren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases. Medicine 2005; 84: 81-89.
Ramos-Casals M, Cervera R, Lagrutta M, et al. Hispanoamerican Study Group of Autoimmune Manifestations of Chronic Viral Disease (HISPAMEC). Clinical features related to antiphospholipid syndrome in patients with chronic viral infections (hepatitis C virus/HIV infection) description of 82 cases. Clin Infect Dis 2004; 38: 1009-1016.
Bassyouni IH, Ezzat Y, Hamdy S, et al. Clinical significance of anti-cyclic citrullinated peptide antibodies in Egyptian patients with chronic hepatitis C virus genotype IV infection. Clin Chem Lab Med 2009; 47: 842-847.
Majdan M. Krioglobulinemia w chorobach reumatycznych. Reumatologia 2007; 45: 391-396.
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