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EDITORIAL ARTICLE
Signet-ring cell adenoma of the thyroid and rheumatoid arthritis: incidental association or methotrexate-related change?
Submission date: 2017-07-07
Acceptance date: 2017-07-11
Online publication date: 2017-08-31
Publication date: 2017-08-31
Reumatologia 2017;55(4):155-156
TOPICS
ABSTRACT
NA (Letter to the Edito section)
Signet-ring cell adenoma of the thyroid and rheumatoid arthritis: incidental association or methotrexate-related change?
Signet-ring cell change in thyroid adenoma is rarely reported [1-3]. We have recently seen such a tumor in case of rheumatoid arthritis (RA) treated by methotrexate. Thyroid tumors are rarely reported in RA patients to our knowledge, mainly of carcinoma-type [4,5]. In conclusion, we report a case of signet-ring cell thyroid adenoma occurring in rheumatoid arthritis treated by methotrexate. The histogenesis of the cytoplasmic vacuoles, negative for thyrocyte classical markes as well as for CD56 and CD138, remains to be elucidated.
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Rosai J. Rosai and Ackerman’s Surgical Pathology.10th Edition Expert Consult. Elsevier Mosby, Philadelphia 2011.
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Bakheet SM, Powe J. Fluorine-18-fluorodeoxyglucose uptake in rheumatoid arthritis-associated lung disease in a patient with thyroid cancer. J Nucl Med 1998; 39: 234-236.
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Otsuka N, Fukunaga M, Morita K, et al. Iodine-131 uptake in a patient with thyroid cancer and rheumatoid arthritis during acupuncture treatment. Clin Nucl Med 1990; 15: 29-31.
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de Mast Q, Haverman J, Netten PM, Sinnige HA. Remission of a primary thyroid lymphoma after methotrexate withdrawal. Clin Endocrinol (Oxf) 2006; 64: 716-717.
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Patterson AM, Cartwright A, David G, et al. Differential expression of syndecans and glypicans in chronically inflamed synovium. Ann Rheum Dis 2008; 67: 592-601.
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Brok HP, Tekoppele JM, Hakimi J, et al. Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys.Clin Exp Immunol 2001; 124: 134-141.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
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