Signet-ring cell adenoma of the thyroid and rheumatoid arthritis: incidental association or methotrexate-related change?
Data nadesłania: 07-07-2017
Data akceptacji: 11-07-2017
Data publikacji online: 31-08-2017
Data publikacji: 31-08-2017
Reumatologia 2017;55(4):155-156
NA (Letter to the Edito section) Signet-ring cell adenoma of the thyroid and rheumatoid arthritis: incidental association or methotrexate-related change? Signet-ring cell change in thyroid adenoma is rarely reported [1-3]. We have recently seen such a tumor in case of rheumatoid arthritis (RA) treated by methotrexate. Thyroid tumors are rarely reported in RA patients to our knowledge, mainly of carcinoma-type [4,5]. In conclusion, we report a case of signet-ring cell thyroid adenoma occurring in rheumatoid arthritis treated by methotrexate. The histogenesis of the cytoplasmic vacuoles, negative for thyrocyte classical markes as well as for CD56 and CD138, remains to be elucidated.
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