Skin melanoma in a rheumatoid arthritis patient treated with infliximab

We present a case of skin melanoma in a 53-year-old patient with rheumatoid arthritis (RA) treated with infliximab and methotrexate. After 12 months of therapy during a routine examination before infusion of infliximab, the enlarging pigmented naevus on the skin of the right arm was prophylactically removed. Histopathological evaluation and immunohistochemistry led to the diagnosis of skin melanoma. We suggest that systematic control of the pigmented naevus during anti-TNF therapy should be strongly recommended.

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