EN PL
ORIGINAL PAPER
The association of pathergy reaction and active clinical presentations of Behçet’s disease
 
More details
Hide details
 
Submission date: 2017-02-17
 
 
Final revision date: 2017-04-05
 
 
Acceptance date: 2017-04-09
 
 
Online publication date: 2017-04-28
 
 
Publication date: 2017-04-28
 
 
Reumatologia 2017;55(2):79-83
 
KEYWORDS
TOPICS
ABSTRACT
Objectives: The pathergy skin test is a hypersensitivity reaction to a prick skin trauma caused by a pin or a needle, which is considered as a specific presentation in Behçet’s disease (BD) and the precise mechanism of this test is not well elucidated. This study was designed to evaluate the association of pathergy reaction (PR) with the active clinical manifestations of BD patients, to assess the clinical importance of PR.
Materials and methods: This was a cohort study on 1675 BD patients who fulfilled the entry criteria based on the International Criteria for Behçet’s Disease (ICBD) from 1975 to 2011. The patients were divided into two groups; the pathergy positive group included 841 patients (50.2%) and the pathergy negative group 834 patients (49.8%). The active mucocutaneous and systemic disease manifestations were analyzed according to the presence of the PR. The odds ratio and 95% confidence interval (95% CI) were calculated for each item.
Results: In this study, 841 patients (50.2%) had a positive pathergy test. Patient’s mean age and mean disease duration were similar in the two groups (pathergy positive and pathergy negative patients). There was no association between positive pathergy test and age of patients, or disease duration. The PR was associated with male gender (p = 0.013), oral aphthosis (p < 0.001), pseudofolliculitis (p < 0.001), anterior uveitis (p = 0.001) and posterior uveitis (p = 0.028).
Conclusions: The presence of PR was associated with male gender, as well as some of mucocutaneous manifestations and uveitis in adult patients. There was no association with retinitis and vascular involvements. PR isn’t associated with the severity of the disease.
 
REFERENCES (18)
1.
Davatchi F. Davatchi F. Behçet’s disease. In: Ashit S.Text book of rheumatology: Principals and Practice. Japee Brotheus; 2010: 249-268.
 
2.
Shahram F, Davatchi F, Akbarian M. The1996 survey of Behcet’s disease in Iran, study of 3153 cases. In: Behçet’s Disease. Hamza M (ed.). Pub Adhoua, Tunisia 1997; 165-169.
 
3.
Gul A, Esin S, Dilsen N, et al. Immunohistology of skin pathergy reaction in Behcet’s disease. Dermatol 1995; 132: 901-907.
 
4.
Chams-Davatchi C, Davatchi F, Shahram F, et al. Longitudinal study of the Pathergy phenomenon in Behcet’s disease. In: Behçet’s Disease. Hamza M (ed.). Pub Adhoua, Tunisia 1997; 356-358.
 
5.
Davatchi F, Shahram F, Chams C, et al. Behçet’s disease. Acta Medica Iranica 2005; 43: 233-242.
 
6.
Davatchi F, Shahram F, Chams-Davatchi C, et al. Behcet’s disease: from east to west. Clin Rheumatol 2010; 29: 823-833.
 
7.
Davatchi F, Chams C, Ghodsi Z. Diagnostic value of Pathergy Test in Behcet’s Disease according to the change of incidence over the time. Clin Rheumatol 2011; 30: 1151-1155.
 
8.
International Team for the Revision of the International Criteria for Behcet’s Disease. Revision of the international criteria for Behcet’s disease (ICBD). Clin Exp Rheumatol 2006; 24: S14-15.
 
9.
Chang HK, Cheon KS. The Clinical Significance of a Pathergy Reaction in Patients with Behcet’s Diseas. J Korean Med Sci 2002; 17: 371-374.
 
10.
Krause I, Molad Y, Mitrani M, et al. Pathergy reaction in Behcet’s disease: lack of correlation with mucocutaneous manifestations and systemic disease expression. Clin Exp Rheumatol 2000; 18: 71-74.
 
11.
Koc Y, Güllü I, Akpek G, et al. Vascular involvement in Behçet’s disease. J Rheumatol 1992; 19: 402-410.
 
12.
Nuran A, Gunes G, Basak Y,et al. Patient characteristics in Behcet’s disease. A retrospective analysis of 213 Turkish patients during 2001-4. Am J Clin Dermatol 2009; 10: 411-418.
 
13.
Davatchi F, Shahram F, Chams-Davatchi C, et al. Behcet’s disease in Iran: analysis of 6500 cases. Int J Rheum Dis 2010; 13: 367-373.
 
14.
Gurler A, Boyvat A, Tursen U. Clinical manifestations of Behçet’s disease: an analysis of 2147 patients. Yonsei Med J 1997; 38: 423-427.
 
15.
Yazici H, Tuzun Y, Tanman AB, et al. Male patients with Behçet’s syndrome have stronger pathergy reactions. Clin Exp Rheumatol 1985; 3: 137-141.
 
16.
Alpsoy E, Elpek O, Yilmaz F, et al. Androgen receptor levels of oral and genital ulcers and skin pathergy test in patients with Behçet’s disease. Dermatology 2005; 210: 31-35.
 
17.
Davatchi F, Chams C, Shahram F, et al. Pathergy test in Behcet’s disease: change in incidence over the time. APLAR J Rheumatology 2007; 10: 333-335.
 
18.
Dilsen N, Konice M, Aral O, et al. Standardization and evaluation of the skin pathergy test in Behcet’s disease and controls. In: Recent advances in Behçet’s disease. Lehner T, Barnes C (eds.). Royal Society of Medicine Services, London 1986: 177-180.
 
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
eISSN:2084-9834
ISSN:0034-6233
Journals System - logo
Scroll to top