The genetic basis of ankylosing spondylitis
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Online publication date: 2007-07-02
Reumatologia 2007;45(3):137-141
Genetic factors provide over 90% of the overall susceptibility to ankylosing spondylitis, with less than 50% of the genetic contribution attributed to HLA-B27 and other major histocompatibility complex genes. Therefore the researcher’s interest has focused on non-major histocompatibility complex genes. The regions implicated in susceptibility to ankylosing spondylitis have been confirmed on chromosomes: 1p, 2q, 3p, 6p (major histocompatibility complex region), 6q, 9q, 10q, 16q, 17p, 19q. Despite use of modern technologies only few non-major histocompatibility complex genes responsible for the susceptibility to ankylosing spondylitis were identified, most notably in the interleukin-1 gene complex.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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