CASE REPORT
Tocilizumab in refractory adult-onset Still’s disease – case report and review of the literature
Online publication date: 2012-06-27
Reumatologia 2012;50(3):238-242
KEYWORDS
ABSTRACT
Adult-onset Still’s disease (AOSD) is an uncommon systemic connective tissue disease, characterized by a typical spiking fever, evanescent rash, arthritis (Fig. 1, 2), hepatosplenomegaly, lymphadenopathy and sore throat. Non-steroidal anti-inflammatory drugs, corticosteroids and immunosuppressants are commonly used as therapeutic agents for AOSD, but some patients are refractory to these conventional therapies. A case of a young woman with severe polyarthritis, refractory to corticosteroids and methotrexate, but successfully treated with the humanized monoclonal anti IL-6 receptor antibody tocilizumab is presented.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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