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REVIEW PAPER
Anaemia of chronic diseases in rheumatoid arthritis
Online publication date: 2010-12-20
Reumatologia 2010;48(6):421-424
KEYWORDS
ABSTRACT
Anaemia of chronic diseases (ACD) is one of the most common hematologic abnormalities in patients with rheumatoid arthritis. It can be observed in a variety of conditions, including neoplastic, infectious and inflammatory diseases, heart failure or diabetes mellitus. However, until recently, little about its pathogenesis has been known. Inflammatory mediators such as tumour necrosis factor-alpha, interleukin-1, interleukin-6 and interlukin-10 play a role in this disorder. Hepcidin is one of key proteins in pathogenesis of ACD as it decreases iron absorption and iron release from macrophages. The pathogenesis of ACD is presented in this paper. Additionally, this review provides a summary of recent studies investigating the role of blocking interleukin-6 in rheumatoid arthritis patients with ACD. Inhibition of the interleukin-6 receptor with tocilizumab leads to an increase in haemoglobin levels as compared to placebo
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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| ISSN: | 0034-6233 |
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