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6/2017 vol. 55
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PRACA PRZEGLĄDOWA
Przeciwciała przeciwjądrowe w chorobach autoimmunologicznych i alergicznych
Bogna Grygiel-Górniak
,
 
Natalia Rogacka
,
 
Michał Rogacki
,
 
Mariusz Puszczewicz
 
 
 
Więcej
Ukryj
 
Data nadesłania: 16-11-2017
 
 
Data ostatniej rewizji: 13-12-2017
 
 
Data akceptacji: 14-12-2017
 
 
Data publikacji online: 30-12-2017
 
 
Data publikacji: 31-12-2017
 
 
Reumatologia 2017;55(6):298-304
DOI: https://doi.org/10.5114/reum.2017.72627
 
 
Artykuł (PDF)
Referencje (65)
 
SŁOWA KLUCZOWE
autoimmune diseases
allergy
antinuclear antibodies
molecular background
 
DZIEDZINY
Diagnostyka laboratoryjna I obrazowa chorób reumatycznych
 
STRESZCZENIE
Antinuclear antibodies (ANA) are primarily significant in the diagnosis of systemic connective tissue diseases. The relationship between their occurrence in allergic diseases is poorly documented. However, the mechanism of allergic and autoimmune diseases has a common thread. In both cases, an increased production of IgE antibodies and presence of ANA in selected disease entities is observed. Equally important is the activation of basophils secreting proinflammatory factors and affecting the differentiation of TH17 lymphocytes. Both autoimmune and allergic diseases have complex multi-pathogenesis and often occur in genetically predisposed individuals. The presence of antinuclear antibodies was confirmed in many systemic connective tissue diseases and some allergic diseases. Examples include atopic dermatitis, non-allergic asthma, and pollen allergy. Co-occurring allergic and autoimmune disorders induce further search for mechanisms involved in the aetiopathogenesis of both groups of diseases.
 
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