EN PL
ORIGINAL PAPER
Characteristics of Polish patients with systemic lupus erythematosus obtained from SESAME registry. Activity of the disease, degree of impairment, and availability of social care
 
More details
Hide details
 
Submission date: 2013-05-22
 
 
Final revision date: 2013-08-14
 
 
Acceptance date: 2013-09-10
 
 
Online publication date: 2013-10-31
 
 
Publication date: 2013-10-30
 
 
Reumatologia 2013;51(5):332-341
 
KEYWORDS
TOPICS
ABSTRACT
The aim of the study was to characterize a large, and as homogeneous as possible, group of Polish patients with systemic lupus erythematosus (SLE). We focused on the sociodemographic characteristics of this group, clinical status at enrollment, and access to healthcare resources.
Material and methods: The study included 269 consecutive patients from six Polish centers for rheumatology, in Bialystok, Katowice, Lublin, Poznań, Warsaw, and Wroclaw, qualified for the international multicenter study SESAME.
Results: The majority of participants were women (n = 234; 87%). Only 28.6% of SLE patients were employed full-time, and about one third of them received disability pension. The studied group included 12% of patients with at least a 6-point SELENA SLEDAI score, who showed a decreased level of complement and tested positively for anti-dsDNA antibodies. Patients whose SELENA SLEDAI scores exceeded 10 points (42%) showed the active involvement of all systems and organs included in the SLE Activity Index, except for skin and mucosal membranes, with a significantly greater frequency than the other groups. The involvement of the musculoskeletal system was also significantly more frequent in patients with SELENA SLEDAI scores between 6 and 10 points (30.5%). We observed a significant association between the activity of the disease and the prevalence of disability or having the support of a social worker.
Conclusions: The population of Polish patients with SLE includes a group of individuals who, due to high activity of the disease confirmed both by physical examination and additional testing, require intensification of the therapeutic protocol. This group can be identified on the basis of the SELENA SLEDAI score. Also, patients with severe disability are characterized by higher activity of the disease. It cannot be excluded that optimal therapeutic control of SLE activity in this group could be reflected by diminished demand for social care services and by a higher level of health-related quality of life.
 
REFERENCES (30)
1.
Firestein GS, Budd RC, Gabriel SE, et al. Kelley's Textbook of Rheumatology 9th ed., Saunders 2013.
 
2.
Cervera R, Khamashta MA, Hughes GR. The Euro-lupus project: epidemiology of systemic lupus erythematosus in Europe. Lupus 2009; 18: 869-874.
 
3.
Bernatsky S, Boivin JF, Joseph L, et al. Mortality in systemic lupus erythematosus. Arthritis Rheum 2006; 54: 2550-2557.
 
4.
Canti V, Castiglioni MT, Rosa S, et al. Pregnancy outcomes in patients with systemic autoimmunity. Autoimmunity 2012; 45: 169-175.
 
5.
Urowitz MB, Gladman DD, Ibanez D, et al. Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort. Arthritis Care Res (Hoboken) 2012; 64: 132-137.
 
6.
Cervera R, Abarca-Costalago M, Abramovicz D, et al. Systemic lupus erythematosus in Europe at the change of the millennium: lessons from the “Euro-Lupus Project”. Autoimmun Rev 2006; 5: 180-186.
 
7.
Chiche L, Jourde N, Ulmann C, et al. Seasonal variations of systemic lupus erythematosus flares in southern France. Eur J Intern Med 2012; 23: 250-254.
 
8.
Guidelines for referral and management of systemic lupus erythematosus in adults. American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines. Arthritis Rheum 1999; 42: 1785-1796.
 
9.
Griffiths B, Mosca M, Gordon C. Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices. Best Pract Res Clin Rheumatol 2005; 19: 685-708.
 
10.
Lu LJ, Wallace DJ, Ishimori ML, et al. Review: Male systemic lupus erythematosus: a review of sex disparities in this disease. Lupus 2010; 19: 119-129.
 
11.
Nossent J, Kiss E, Rozman B, et al. Disease activity and damage accrual during the early disease course in a multinational inception cohort of patients with systemic lupus erythematosus. Lupus 2010; 19: 949-956.
 
12.
Sardu C, Cocco E, Mereu A, et al. Population based study of 12 autoimmune diseases in Sardinia, Italy: prevalence and comorbidity. PLoS One 2012; 7: e32487.
 
13.
Cerovec M, Anic B, Padjen I, et al. Prevalence of the American College of Rheumatology classification criteria in a group of 162 systemic lupus erythematosus patients from Croatia. Croat Med J 2012; 53: 149-154.
 
14.
Monjardino T, Lucas R, Barros H. Frequency of rheumatic diseases in Portugal: a systematic review. Acta Reumatol Port 2011; 36: 336-363.
 
15.
Shoenfeld Y, Tincani A, Gershwin ME. Sex gender and autoimmunity. J Autoimmun 2012; 38: J71-73.
 
16.
Mok CC, Lau CS, Chan TM, et al. Clinical characteristics and outcome of southern Chinese males with systemic lupus erythematosus. Lupus 1999; 8: 188-196.
 
17.
Schwartzman-Morris J, Putterman C. Gender differences in the pathogenesis and outcome of lupus and of lupus nephritis. Clin Dev Immunol 2012; 2012: 604892.
 
18.
Stefanidou S, Benos A, Galanopoulou V, et al. Clinical expression and morbidity of systemic lupus erythematosus during a post-diagnostic 5-year follow-up: a male:female comparison. Lupus 2011; 20: 1090-1094.
 
19.
Voulgari PV, Katsimbri P, Alamanos Y, et al. Gender and age differences in systemic lupus erythematosus. A study of 489 Greek patients with a review of the literature. Lupus 2002; 11: 722-729.
 
20.
Grzegorczyk K, Krajewska M, Weyde W, et al. [Gender and kidney diseases: the clinical importance and mechanisms of modifying effects]. Postepy Hig Med Dosw (Online) 2011; 65: 849-857.
 
21.
Gandolfo MT, Verzola D, Salvatore F, et al. Gender and the progression of chronic renal diseases: does apoptosis make the difference? Minerva Urol Nefrol 2004; 56: 1-14.
 
22.
Zhang J, Gonzalez LA, Roseman JM, et al. Predictors of the rate of change in disease activity over time in LUMINA, a multiethnic US cohort of patients with systemic lupus erythematosus: LUMINA LXX. Lupus 2010; 19: 727-733.
 
23.
Marker-Hermann E, Fischer-Betz R. Rheumatic diseases and pregnancy. Curr Opin Obstet Gynecol 2010; 22: 458-465.
 
24.
Yan Yuen S, Krizova A, Ouimet JM, et al. Pregnancy outcome in systemic lupus erythematosus (SLE) is improving: Results from a case control study and literature review. Open Rheumatol J 2008; 2: 89-98.
 
25.
Clowse ME, Magder LS, Witter F, et al. The impact of increased lupus activity on obstetric outcomes. Arthritis Rheum 2005; 52: 514-521.
 
26.
Petri M. Prospective study of systemic lupus erythematosus pregnancies. Lupus 2004; 13: 688-689.
 
27.
Wei Q, Ouyang Y, Zeng W, et al. Pregnancy complicating systemic lupus erythematosus: a series of 86 cases. Arch Gynecol Obstet 2011; 284: 1067-1071.
 
28.
Chen CY, Chen YH, Lin HC, et al. Increased risk of adverse pregnancy outcomes for hospitalisation of women with lupus during pregnancy: a nationwide population-based study. Clin Exp Rheumatol 2010; 28: 49-55.
 
29.
Mazzoni D, Cicognani E. Social support and health in patients with systemic lupus erythematosus: a literature review. Lupus 2011; 20: 1117-1125.
 
30.
Bugajska J, Brzosko M, Jedryka-Goral A, et al. Psychological stress in rheumatoid arthritis patients: a comparative Polish-German study: summary of the current conceptualization of the role of stress in rheumatoid arthritis. Autoimmun Rev 2010; 9: 211-215.
 
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
eISSN:2084-9834
ISSN:0034-6233
Journals System - logo
Scroll to top