REVIEW PAPER
Color fraction as a useful method of imaging synovium vascularization in patients with high activity of rheumatoid arthritis
More details
Hide details
1
Early Arthritis Clinic, National Institute of Geriatric, Rheumatology and Rehabilitation, Warsaw, Poland
2
Department of Radiology, National Institute of Geriatric, Rheumatology and Rehabilitation, Warsaw, Poland
Submission date: 2020-01-29
Final revision date: 2020-02-14
Acceptance date: 2020-02-19
Online publication date: 2020-02-28
Publication date: 2020-02-28
Reumatologia 2020;58(1):42-47
KEYWORDS
TOPICS
ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease with joint inflammation and destruction as the main features that appears with prevalence of 1 to 2% of the general population. Women are three times more likely to suffer from RA than men. Rheumatoid arthritis occurs at any age but commonly over 40–50 years old. In the course of RA each joint may be involved but most frequently the proximal interphalangeal and metacarpophalangeal joints of the hands, wrists, and also small joints of the feet are affected.
Symmetrical joint swelling with overgrowth of synovium and hypervascularization confirmed in power Doppler ultrasound imaging are very characteristic for RA. Quantification of vascularization with the color fraction index may be a useful tool to monitor disease activity and in evaluation of inflammation in scientific research.
This article aims to present this imaging diagnostic method based on the literature.
REFERENCES (30)
1.
Hassan R, Hussain S, Bacha R, et al. Reliability of Ultrasound for the Detection of Rheumatoid Arthritis. J Med Ultrasound 2019; 27: 3-12, DOI: 10.4103/JMU.JMU_112_18.
2.
Ostrowska M, Maśliński W, Prochorec-Sobieszek M, et al. Cartilage and bone damage in rheumatoid arthritis. Reumatologia 2018; 56: 111-120, DOI: 10.5114/reum.2018.75523.
3.
Rubin JM, Adler RS, Fowlkes JB, et al. Fractional moving blood volume: estimation with power Doppler US. Radiology 1995; 197: 183-190, DOI: 10.1148/radiology.197.1.7568820.
4.
Rubin JM, Bude RO, Carson PL, et al. Power Doppler US: a potentially useful alternative to mean frequency-based color Doppler US. Radiology 1994; 190: 853-856, DOI: 10.1148/ radiology.190.3.8115639.
5.
Padovano I, Costantino F, Breban M, et al. Prevalence of ultrasound synovial inflammatory findings in healthy subjects. Ann Rheum Dis 2016; 75: 1819-1823, DOI: 10.1136/annrheumdis 2015-208103.
6.
Schmidt WA, Völker L, Zacher J, et al. Colour Doppler ultrasonography to detect pannus in knee joint synovitis. Clin Exp Rheumatol 2000; 18: 439-444.
7.
Torp-Pedersen S, Szkudlarek M, Ellegaard K, et al. Colour or Power Doppler – which is more sensitive and do machine settings matter? Ann Rheum Dis 2012; 71 (Suppl 3): 603, DOI: 10.1136/annrheumdis-2012-eular.3335.
8.
Kasukawa R, Shio K, Kanno Y, et al. Power Doppler and spectral Doppler measurements of knee-joint synovitis in rheumatoid arthritis patients with superficial pattern signals and in those with deep pattern signals. Mod Rheumatol 2007; 17: 267-272, DOI: 10.1007/s10165-007-0588-5.
9.
Szkudlarek M, Court-Payen M, Jacobsen S, et al. Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis. Arthritis Rheum 2003; 48: 955-962, DOI: 10.1002/art.10877.
10.
Schmidt WA, Schönau V, Reiche BE, et al. Grading of ultrasound Doppler signals in synovitis: does it need an update? Rheumatology (Oxford) 2015; 54: 1897-1903, DOI: 10.1093/rheumatology/kev205.
11.
Torp-Pedersen S, Christensen R, Szkudlarek M, et al. Power and Color Doppler Ultrasound Settings for Inflammatory Flow,Impact on Scoring of Disease Activity in Patients With Rheumatoid Arthritis. Arthritis Rheum 2015; 67: 386-395, DOI: 10.1002/art.3894.
12.
Ellegard K, TorpPedersen S, Terslev L, et al. Ultrasound colour Doppler measurements in a single joint as measure of disease activity in patients with rheumatoid arthritis – assessment of concurrent validity. Rheumatology (Oxford) 2009; 48: 254-257, DOI: 10.1093/rheumatology/ken459.
13.
Dougados M, Jousse-Joulin S, Mistretta F, et al. Evaluation of several ultrasonography scoring systems for synovitis and comparison to clinical examination: results from a prospective multicentre study of rheumatoid arthritis. Ann Rheum Dis 2010; 69: 828-833, DOI: 10.1136/ard.2009.115493.
14.
Naredo E, Collado P, Cruz A, et al. Longitudinal power Doppler ultrasonographic assessment of joint inflammatory activity in early rheumatoid arthritis: predictive value in disease activity and radiologic progression. Arthritis Rheum 2007; 57: 116-124, DOI: 10.1002/art.22461.
15.
Backhaus TM, Ohrndorf S, Kellner H, et al. The US7 score is sensitive to change in a large cohort of patients with rheumatoid arthritis over 12 months of therapy. Ann Rheum Dis 2013; 72: 1163-1169, DOI: 10.1136/annrheumdis-2012-201397.
16.
Naredo E, Möller I, Cruz A, et al. Power Doppler ultrasonographic monitoring of response to antitumor necrosis factor therapy in patients with rheumatoid arthritis. Arthritis Rheum 2008; 58: 2248- 2256, DOI: 10.1002/art.23682.
17.
Hammer HB, Sveinsson M, Kongtorp AK, Kvien TK. A 78-joints ultrasonographic assessment is associated with clinical assessments and is highly responsive to improvement in a longitudinal study of patients with rheumatoid arthritis starting adalimumab treatment. Ann Rheum Dis 2010; 69: 1349-1351, DOI: 10.1136/ard.2009.126995.
18.
Seymour MW, Kelly S, Beals CR, et al. Ultrasound of metacarpophalangeal joints is a sensitive and reliable endpoint for drug therapies in rheumatoid arthritis: results of a randomized, two-center placebo-controlled study. Arthritis Res Ther 2012; 14: R198, DOI: 10.1186/ar4034.
19.
Andersen M, Ellegaard K, Hebsgaard JB, et al. Ultrasound colour Doppler is associated with synovial pathology in biopsies from hand joints in rheumatoid arthritis patients: a cross-sectional study. Ann Rheum Dis 2014; 73: 678-683, DOI: 10.1136/annrheumdis-2012-202669.
20.
Terslev L, Torp-Pedersen S, Qvistgaard E, et al. Estimation of inflammation by Doppler ultrasound: quantitative changes after intra-articular treatment in rheumatoid arthritis. Ann Rheum Dis 2003; 62: 1049-1053, DOI: 10.1136/ard.62.11.1049.
21.
Terslev L, Ellegaard K, Christensen R, et al. Head-to-head comparison of quantitative and semi-quantitative ultrasound scoring systems for rheumatoid arthritis: reliability, agreement and construct validity. Rheumatology (Oxford) 2012; 51: 2034-2038, DOI: 10.1093/rheumatology/kes124.
22.
Terslev L, Torp-Pedersen S, Qvistgaard E, et al. Doppler ultrasound findings in healthy wrists and finger joints. Ann Rheum Dis 2004; 63: 644-648, DOI: 10.1136/ard.2003.00954.
23.
Ponikowska M, Świerkot J, Nowak B. The importance of ultrasound examination in early arteritis. Reumatologia 2018; 56: 354-361, DOI: 10.5114/reum.2018.80712.
24.
McQueen FM, Benton N, Perry D, et al. Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis. Arthritis Rheum 2003; 48: 1814-1827, DOI: 0.1002/art.11162.
25.
Sudoł-Szopińska I, Jans L, Teh J. Rheumatoid arthritis: what do MRI and ultrasound show. J Ultrason 2017; 17: 5-16.
26.
Ohrndorf S, Boer AC, Boeters DM, et al. Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia. Arthritis Res Ther 2019; 21: 59, DOI: 10.1186/s13075-019-1824-z.
27.
Vordenbäumen S, Schleich C, Lögters T, et al. Dynamic contrast-enhanced magnetic resonance imaging of metacarpophalangeal joints reflects histological signs of synovitis in rheumatoid arthritis. Arthritis Res Ther 2014; 16: 452, DOI: 10.1186/s13075-014-0452-x.
28.
Jans L, De Kock I, Herregods N, et al. Dual-energy CT: a new imaging modality for bone marrow oedema in rheumatoid arthritis. Ann Rheum Dis 2018; 77: 958-960, DOI: 10.1136/annrheumdis-2018-213152.
29.
Haavardsholm EA, Olsen IC, Hammer HB, et al. Ultrasound in management of rheumatoid arthritis: ARCTIC randomised controlled strategy trial. BMJ 2016; 354, i4205, DOI:
https://doi.org/10.1136/bmj.i4....
30.
Dale J, Stirling A, Zhang R, et al. Targeting ultrasound remission in early rheumatoid arthritis: the results of the TaSER study, a randomised clinical trial. Ann Rheum Dis 2016; 75: 1043-1050, DOI: 10.1136/annrheumdis-2015-208941.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (
https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.