EN PL
 
EN PL
Current issue
Archive
Online first
About the Journal
Instructions for authors
Books and Events
6/2014 vol. 52
Get citation
REVIEW PAPER
IgG4-related disease and systemic vasculitis – is there any connection?
Anna Masiak
,
 
Zbigniew Zdrojewski
 
 
 
More details
Hide details
 
Submission date: 2014-05-12
 
 
Final revision date: 2014-08-18
 
 
Acceptance date: 2014-11-05
 
 
Online publication date: 2014-11-30
 
 
Publication date: 2014-12-31
 
 
Reumatologia 2014;52(6):384-387
DOI: https://doi.org/10.5114/reum.2014.47232
 
 
Article (PDF)
References (38)
 
KEYWORDS
IgG4-related diseases
systemic vasculitis
ANCA antibody
 
TOPICS
Vasculitis - aetiology, pathogenesis, clinical features and treatment
Diagnostics and imaging in rheumatic diseases
 
ABSTRACT
IgG4-related disease is a relatively new group of diseases of still unknown etiology. It is characterized by elevated serum levels of subclass IgG4 immunoglobulin and by abundant infiltration of IgG4+ plasma cells with typical fibrosis of the affected organs. Elevated concentration of IgG4 may be present in many other conditions associated with chronic inflammation. In recent years, it is noted that this may also apply to patients with systemic vasculitis, in particular antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The aim of this study is to draw attention to the fact that in some cases, both clinical presentation and histopathological findings in IgG4-related diseases and systemic vasculitis may be similar. The importance of elevated serum IgG4 immunoglobulin in patients with ANCA-associated vasculitis (AAV) is unclear and requires further research.
 
REFERENCES (38)
1.
Khosroshahi A, Stone JH. A clinical overview of IgG4-related systemic disease. Curr Opin Rheumatol 2011; 23: 57-66. .
Google Scholar
 
 
2.
Stone JH, Khosroshahi A, Deshpande V, et al. Recommendations for the Nomenclature of IgG4-related disease and its individual organ system manifestations. Arthritis Rheum 2012; 64: 3061-3067. .
Google Scholar
 
 
3.
Stone JH, Zen Y, Deshpande V. IgG4-related disease. N Engl J Med 2012; 366: 539-551. .
Google Scholar
 
 
4.
Deshpande V, Zen Y, Chan JK, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol 2012; 25: 1181-1192. .
Google Scholar
 
 
5.
Zen Y, Nakanuma Y. IgG4-related disease: a cross sectional study of 114 cases. Am J Surg Pathol 2010; 34: 1812-1819. .
Google Scholar
 
 
6.
Umehara H, Okazaki K, Masaki Y, et al. Comprehensive diagnostic criteria for IgG4-realted disease (IgG4-RD), 2011. Mod Rheumatol 2012; 22: 21-30. .
Google Scholar
 
 
7.
Sato Y, Notohara K, Kojima M, et al. IgG4-related disease: historical overview and pathology of hematological disorders. Pathol Int 2010; 60: 247-258. .
Google Scholar
 
 
8.
Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy 2009; 39: 469-477. .
Google Scholar
 
 
9.
Murata K, Fox-Talbot K, Qian Z, et al. Synergistic deposition of C4d by complement-activating and non-activating antibodies in cardiac transplants. Am J Transplant 2007; 7: 2605-2614. .
Google Scholar
 
 
10.
Della Torre E, Mattoo H, Mahajan VS, et al. Prevalence of atopy, eosinophilia, and IgE elevation in IgG4-related disease. Allergy 2014; 69: 269-272. .
Google Scholar
 
 
11.
Kanari H, Kagami S, Kashiwakuma D, et al. Role of Th2 cells in IgG4-related lacrimal gland enlargement. Int Arch Allergy Immunol 2010; 152 Suppl 1: 47-53. .
Google Scholar
 
 
12.
Suzuki K, Tamaru J, Okuyama A, et al. IgG-4 positive multiorgan lymphoproliferative syndrome manifesting as chronic symmetrical sclerosing dacryo-sialadenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation. Rheumatology (Oxford) 2010; 49: 1789-1791. .
Google Scholar
 
 
13.
Kamisawa T, Anjiki H, Egawa N, Kubota N. Allergic manifestations in autoimmune pancreatitis. Eur J Gastroenterol Hepatol 2009; 21: 1136-1139. .
Google Scholar
 
 
14.
Kawano M, Saeki T, Nakashima H, et al. Proposal for diagnostic criteria for IgG4-related kidney disease. Clin Exp Nephrol 2011; 15: 615-626. .
Google Scholar
 
 
15.
Raissian Y, Nasr SH, Larsen CP, et al. Diagnosis of IgG4-related tubulointerstitial nephritis. J Am Soc Nephrol 2011; 22: 1343-1352. .
Google Scholar
 
 
16.
Alexander MP, Larsen CP, Gibson IW, et al. Membranous glomerulonephritis is a manifestation of IgG4-related disease. Kidney Int 2013; 83: 455-462. .
Google Scholar
 
 
17.
Stone JR. Aortitis, periaortitis, and retroperitoneal fibrosis, as manifestations of IgG4-related systemic disease. Curr Opin Rheumatol 2011; 23: 88-94. .
Google Scholar
 
 
18.
Kasashima S, Zen Y. IgG4-related inflammatory abdominal aortic aneurysm. Curr Opin Rheumatol 2011; 23: 18-23. .
Google Scholar
 
 
19.
Perez Alamino R, Martínez C, Espinoza LR. IgG4-associated vasculitis. Curr Rheumatol Rep 2013; 15: 348. .
Google Scholar
 
 
20.
Kawakami T, Yamaguchi N, Soma Y, et al. Immunoglobulin G4-related disease associated with cutaneous vasculitis. Acta Derm Venereol 2014; 94: 327-328. .
Google Scholar
 
 
21.
Tamai R, Hasegawa Y, Hisano S, et al. A case of IgG4-related tubulointerstitial nephritis concurrent with Henoch-Schönlein purpura nephritis. Allergy Asthma Clin Immunol 2011; 7: 5. .
Google Scholar
 
 
22.
Wakamatsu R, Watanabe H, Suzuki K, et al. Hypocomplementemic urticarial vasculitis syndrome is associated with high levels of serum IgG4: a clinical manifestation that mimics IgG4-related disease. Intern Med 2011; 50: 1109-1112. .
Google Scholar
 
 
23.
Strehl JD, Hartmann A, Agaimy A. Numerous IgG4-positive plasma cells are ubiquitous in diverse localised non-specific chronic inflammatory conditions and need to be distinguished from IgG4-related systemic disorders. J Clin Pathol 2011; 64: 237-243. .
Google Scholar
 
 
24.
Yamamoto M, Tabeya T, Naishiro Y, et al. Value of serum IgG4 in the diagnosis of IgG4-related disease and in differentiation from rheumatic diseases and other diseases. Mod Rheumatol 2012; 22: 419-425. .
Google Scholar
 
 
25.
Ryu JH, Horie R, Sekiguchi H, et al. Spectrum of disorders associated with elevated serum IgG4 levels in clinical practice. Int J Rheumatol 2012; 2012: 232960. .
Google Scholar
 
 
26.
Ebbo M, Grados A, Bernit E, et al. Pathologies associated with serum IgG4 elevation. Int J Rheumatol 2012; 2012: 602809. .
Google Scholar
 
 
27.
Carruthers MN, Khosroshahi A, Augustin T, et al. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease. Ann Rheum Dis 2014, Mar 20 [Epub ahead of print]. .
Google Scholar
 
 
28.
Yamamoto M, Takahashi H, Suzuki C, et al. Analysis of serum IgG subclasses in Churg-Strauss syndrome: the meaning of elevated serum levels of IgG4. Intern Med 2010; 49: 1365-1370. .
Google Scholar
 
 
29.
Ayuzawa N, Ubara Y, Keiichi S, et al. Churg-Strauss syndrome with a clinical condition similar to IgG4-related kidney disease: a case report. Intern Med 2012; 51: 1233-1238. .
Google Scholar
 
 
30.
Vaglio A, Strehl JD, Manger B, et al. IgG4 immune response in Churg-Strauss syndrome. Ann Rheum Dis 2012; 71: 390-393. .
Google Scholar
 
 
31.
Devaney KO, Travis WD, Hoffman G, et al. Interpretation of head and neck biopsies in Wegener’s granulomatosis. A pathologic study of 126 biopsies in 70 patients. Am J Surg Pathol 1990; 14: 555-564. .
Google Scholar
 
 
32.
Chang SY, Keogh KA, Lewis JE, et al. IgG4-positive plasma cells in granulomatosis with polyangiitis (Wegener’s): a clinicopathologic and immunohistochemical study on 43 granulomatosis with polyangiitis and 20 control cases. Hum Pathol 2013; 44: 2432-2437. .
Google Scholar
 
 
33.
Brouwer E, Tervaert JW, Horst G, et al. Predominance of IgG1 and IgG4 subclasses of antineutrophil cytoplasmatic autoantibodies (ANCA) in patients with Wegener’s granulomatosis and clinically related disorders. Clin Exp Immunol 1991; 83: 379-386. .
Google Scholar
 
 
34.
Colman R, Hussain A, Goodall M, et al. Chimeric antibodies to proteinase 3 of IgG1 and IgG3 subclasses induce different magnitudes of functional responses in neutrophils. Ann Rheum Dis 2007; 66: 676-682. .
Google Scholar
 
 
35.
Holland M, Hewins P, Goodall M, et al. Anti-neutrophil cytoplasm antibody IgG subclasses in Wegener’s granulomatosis: a possible pathogenic role for the IgG4 subclass. Clin Exp Immunol 2004; 138: 183-192. .
Google Scholar
 
 
36.
Liu LJ, Chen M, Yu F, et al. IgG subclass distribution, affinity of anti-myeloperoxidase antibodies in sera from patients with Wegener’s granulomatosis and microscopic polyangiitis. Nephrology 2008; 13: 629-635. .
Google Scholar
 
 
37.
Hussain A, Pankhurst T, Goodall M, et al. Chimeric IgG4 PR3-ANCA induces selective inflammatory responses from neutrophils through engagement of Fcγ receptors. Immunology 2009; 128: 236-244. .
Google Scholar
 
 
38.
Pankhurst T, Nash G, Williams J, et al. Immunoglobulin subclass determines ability of immunoglobulin (Ig)G to capture and activate neutrophils presented as normal human IgG or disease-associated anti-neutrophil cytoplasm antibody (ANCA)-IgG. Clin Exp Immunol 2011; 164: 218-226.
Google Scholar
 
 
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
Send by email
RELATED ARTICLE
Pulmonary pattern in systemic vasculitis: granulomatosis, lung cancer or both?
Mikulicz’s disease and Küttner’s tumor as manifestations of IgG4-related diseases: a review of the literature
Coexistence of granulomatosis with polyangiitis (GPA) and Crohn’s disease or multiorgan manifestation of the same disease?
Granulomatosis with polyangiitis – diagnostic difficulties?
Sjögren’s syndrome versus IgG4-related diseases – classification difficulties and treatment progress
Indexes
 
Keywords index
Topics index
Authors index
eISSN:2084-9834
ISSN:0034-6233
Journals System - logo
© 2006-2024 Journal hosting platform by Bentus
Scroll to top