EN PL
PRACA PRZEGLĄDOWA
Choroba IgG4-zależna a układowe zapalenie naczyń – czy istnieje jakiś związek?
 
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Data nadesłania: 12-05-2014
 
 
Data ostatniej rewizji: 18-08-2014
 
 
Data akceptacji: 05-11-2014
 
 
Data publikacji online: 30-11-2014
 
 
Data publikacji: 31-12-2014
 
 
Reumatologia 2014;52(6):384-387
 
SŁOWA KLUCZOWE
DZIEDZINY
STRESZCZENIE
Choroby IgG4-zależne to stosunkowo nowa grupa schorzeń o niewyjaśnionej dotychczas etiologii. Charakteryzują się one zwiększonym stężeniem podklasy IgG4 immunoglobulin w surowicy i naciekami tkankowymi z komórek IgG4-dodatnich z typowym włóknieniem zajętych narządów. Zwiększone stężenie IgG4 może występować w wielu innych chorobach przebiegających z przewlekłym stanem zapalnym. W ostatnich latach zwraca się uwagę, że może to dotyczyć również chorych na układowe zapalenia naczyń, szczególnie ANCA-dodatnie. Celem niniejszego opracowania jest chęć zwrócenia uwagi na fakt, iż w niektórych przypadkach zarówno objawy kliniczne, jak i obraz histopatologiczny chorób IgG4-zależnych i układowych zapaleń naczyń mogą być podobne. Znaczenie zwiększonego stężenia IgG4 u chorych z AAV (ANCA-associated vasculitis) jest niejasne i wymaga dalszych badań.
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