REVIEW PAPER
Influence of leptin and adiponectin on chondrogenesis and osteoblastogenesis. A potential role in rheumatoid arthritis pathogenesis
Online publication date: 2011-05-06
Reumatologia 2011;49(2):126-131
KEYWORDS
ABSTRACT
Leptin and adiponectin are classic adipokines produced in the white adipose tissue. They exert pleiotropic effects on organism and currently their role in rheumatoid arthritis and osteoarthritis is intensively studied. The role of adiponectin and leptin in chondrogenesis and osteogenesis is still unclear. These processes are crucial in rheumatoid arthritis because of massive destruction of joint cartilage and bone in this disease. The influence of these two adipokines must be elucidated as well as their influence on differentiation of mesenchymal stem cells. In this article we present current knowledge on adiponectin and leptin influence on chondrogenesis and osteoblastogenesis (Table I, II).
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
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