Current issue
Archive
Online first
About the Journal
Editorial Office
Editorial Board
Publisher
Editorial Policies
Ethical standards and procedures
Abstracting and indexing
Reviewers
Honorary Reviewers
Subscription
Contact
Most read articles
Instructions for authors
Article processing charge (APC)
Books and Events
Books
Events
REVIEW PAPER
Influence of leptin and adiponectin on chondrogenesis and osteoblastogenesis. A potential role in rheumatoid arthritis pathogenesis
Online publication date: 2011-05-06
Reumatologia 2011;49(2):126-131
KEYWORDS
ABSTRACT
Leptin and adiponectin are classic adipokines produced in the white adipose tissue. They exert pleiotropic effects on organism and currently their role in rheumatoid arthritis and osteoarthritis is intensively studied. The role of adiponectin and leptin in chondrogenesis and osteogenesis is still unclear. These processes are crucial in rheumatoid arthritis because of massive destruction of joint cartilage and bone in this disease. The influence of these two adipokines must be elucidated as well as their influence on differentiation of mesenchymal stem cells. In this article we present current knowledge on adiponectin and leptin influence on chondrogenesis and osteoblastogenesis (Table I, II).
REFERENCES (41)
1.
Lee GH, Proenca R, Montez GH, et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635. .
3.
Otero M, Lago R, Gomez R, et al. Towards a pro-inflammatory and immunomodulatory emerging role of leptin. Rheumatology (Oxford) 2006; 45: 944-950. .
4.
Caetano-Lopes J, Canha~o H, Fonseca J. Osteoblasts and bone formation. Acta Reumatol Port 2007; 32: 103-110. .
5.
Kershaw E, Flier J. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548-2556. .
6.
Neumeier M, Weigert J, Schäffler A, et al. Different effects of adiponectin isoforms in human mononocytic cells. J Leuk Biol 2006; 79: 803-808. .
7.
Song H, Chan J, Rovin B, et al. Induction of chemokine expression by adiponectin in vitro is isoform dependent. Trans Res 2009; 154: 18-26. .
8.
Djouad F, Buffi C, Ghannam S, et al. Mesenchymal stem cells: innovative therapeutic tools for rheumatic diseases. Nat Rev Rheum 2009; 5: 392-399. .
9.
Gonza`lez M, Gonzales-Rey E, Rico L, et al. Treatment of experimental arthritis by inducing immune tolerance with human adipose-derived mesenchymal stem cells. Arthritis Rheum 2009; 60: 1006-1019. .
10.
Komori T. Regulation of osteoblasts differentiation by transcriptional factors. J Cell Biochem 2006; 99: 1233-1239. .
12.
Andreas K, Häupl T, Lübke C, et al. Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther 2009; 11: R15. .
13.
Voorzanger-Rousselot N, Charni Ben-Tabassi N, Garnero P, et al. Opposite relationships between circulating Dkk-1 and cartilage breakdown in patients with .
15.
Otero M, Lago R, Gomez R, et al. Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis. Ann Rheum Dis 2006; 65: 1198-1201. .
16.
Schäffler A, Ehling A, Neumann E, et al. Adipocytokines in synovial fluid. JAMA 2003; 290: 1709-1710. .
17.
Lago R, Gomez R, Otero M, et al. A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocyte. Osteoarthritis Cartilage 2008; 16: 1101-1109. .
18.
Frommer K, Zimmermann B, Schröder D, et al. Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritis. Arthritis Rheum 2010; 62: 2886-2899. .
19.
Challa T, Rais Y, Ornan E, et al. Effect of adiponectin on ATDC5 proliferation, differentiation and signaling pathways. Mol Cell Endocrinol 2010; 323: 282-291. .
20.
Goldstein B, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metabol 2004; 89: 2563-2568. .
21.
Berner H, Lyngstadaas S, Spahr A, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004; 35: 842-849. .
22.
Luo X, Guo L, Yuan L, et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Exp Cell Res 2005; 309: 99-109. .
23.
Oshima K, Nampei A, Matsuda M, et al. Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 2005; 331: 520-526. .
24.
Williams G, Wang Y, Callon K. In vitro and in vivo effects of adiponectin on bone Endocrinology 2009; 150: 3603-3610. .
25.
Lee H, Kim S, Kim A, et al. Adiponectin stimulates osteoblast differentiation through induction of COX2 in mesenchymal progenitor cells. Stem Cells 2009; 27: 2254-2262. .
26.
Luo X, Guo L, Xie H, et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblast through the MAPK signaling pathway. J Bone Miner Res 2006; 21: 1648-1656. .
27.
Targońska-Stępniak B, Majdan M, Dryglewska M, et al. Adiponectin and leptin serum concentration in patients with rheumatoid arthritis. Rheumatol Int 2010; 30: 731-737. .
28.
Maciejewska-Stelmach J, Śliwińska-Stańczyk P, Łącki J i wsp. Znaczenie leptyny w układowych zapalnych chorobach tkanki łącznej. Reumatologia 2007; 45: 219-224. .
29.
Figenshau Y, Knutsen G, Shahazeydi S, et al. Human articular chondrocytes express functional leptin receptors. Biochem Biophys Res Commun 2001; 14: 190-197. .
30.
Ben-Eliezer M, Philip M, Gat-Yablonski G. Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways. Endocrine 2007; 32: 235-244. .
31.
Ohba S, Lanigan T, Roessler B, et al. Leptin receptor JAK2/STAT3 signaling modulates expression of frizzled receptors in articular chondrocytes. Osteoarthritis Cartilage 2010; 18: 1620-1629. .
32.
Otero M, Gomez Reino J, Gualillo O. Synergistic induction of nitric oxide synthase type II. In vitro effect of leptin and interferon- in human chondrocytes and ATDC5 chondrogenic cells. Arthritis Rheum 2003; 48: 404-409. .
33.
Amin A, Abramson S. The role of nitric oxide in articular cartilage breakdown in osteoarthritis. Curr Opin Rheumatol 1998; 10: 263-268. .
34.
Hashimoto S, Ochs RL, Komiya S, Lotz M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum 1998; 41: 1632-1638. .
35.
Nagy G, Koncz A, Telarico T, et al. Central role of nitric oxide in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus. Arthritis Res Ther 2010; 12: 210-215. .
36.
Gordeladze J, Drevon C, Syversen U, et al. Leptin stimulates human osteoblastic cell proliferation de novo collagen synthesis and mineralization: impact on differentiation markers, apoptosis and osteoclastic signaling. J Cell Biochem 2002; 85: 825-836. .
37.
Lamghari M, Tavares L, Camboa N, et al. Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts. J Cell Biochem 2005; 98: 1123-1129. .
38.
Guosheng H, Yingying J, Zhang Y, et al. Osteogenic differentiation of bone marrow mesenchymal stem cells by adenovirus-mediated expression of leptin. Regul Pept 2010; 163: 107-112. .
39.
Skalska U, Burakowski T, Janicka I, et al. Adipose derived stem cells in cartilage and bone repair in rheumatoid arthritis. Int Immunol 2010; 22: suppl. 1: ii103. .
40.
Dudics V, Kunsta A, Kovacs J, et al. Chondrogenic potential of mesenchymal stem cells from patirnets with rheumatoid arthritis and osteoarthritis: measurements in a microculture system. Cells Tissues Organs 2009; 189: 307-316. .
41.
Roubenoff R. Rheumatoid cachexia: a complication of rheumatoid arthritis moves into the 21st century. Arthritis Res Ther 2009; 11: 2-3.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
RELATED ARTICLE
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
