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PRACA PRZEGLĄDOWA
Wpływ leptyny i adiponektyny na procesy chondro genezy i osteoblastogenezy – znaczenie w patogenezie reumatoidalnego zapalenia stawów
 
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Data publikacji online: 06-05-2011
 
 
Reumatologia 2011;49(2):126-131
 
SŁOWA KLUCZOWE
STRESZCZENIE
Leptyna i adiponektyna to klasyczne adipokiny produkowane przez białą tkankę tłuszczową. Mają one działanie plejotropowe; ich rolę bada się w takich chorobach, jak reumatoidalne zapalenie stawów czy choroba zwyrodnieniowa stawów. Dotąd nie wiadomo, jaki dokładnie wpływ wywierają one na procesy chondrogenezy i osteoblastogenezy. Te dwa procesy są bardzo istotne z punktu widzenia reumatoidalnego zapalenia stawów, gdyż w chorobie tej dochodzi do destrukcji chrząstki i kości stawowej. Istotne jest określenie, jaką rolę odgrywają adipokiny w reumatoidalnym zapaleniu stawów oraz w jaki sposób wpływają na różnicowanie komórek mezenchymalnych. W niniejszej pracy przedstawiono obecną wiedzę na temat roli adiponektyny i leptyny w procesach osteogenezy i chondrogenezy (tab. I i II).
 
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