REVIEW PAPER
Prevalence of anti-thyroid antibodies and thyroid dysfunction in selected rheumatic diseases
Online publication date: 2011-05-06
Reumatologia 2011;49(2):132-137
KEYWORDS
ABSTRACT
Autoimmune thyroid disorders are the most frequent organ-specific autoimmune diseases. The presence of autoantibodies to the thyroid gland is distinctive. The major antigens in thyroid autoimmune diseases are thyroid peroxidase and TSH receptor. The presence of thyroid autoantibodies in other autoimmune diseases is more frequent then in general population. Hypothyroidism is the most frequent autoimmune thyroid disorder in extra thyroid diseases, and the presence of thyroid auto antibodies is associated with higher risk of hypothyroidism. Among connective tissue diseases primary Sjögren Syndrome mostly coexists with autoimmune thyroid disorders. The presence of thyroid auto antibodies is also frequent in rheumatoid arthritis and lupus erythematosus patients. The experts' opinions regarding recommendations of thyroid function screening in rheumatic disease are not homogeneous, but this screening is recommended in primary Sjögren Syndrome, rheumatoid arthritis and lupus erythematosus patients.
REFERENCES (54)
1.
Czarnocka B. Thyroid peroxidase – enzyme and antigen. Thyroid International 2006; 3. .
2.
Belyavin G, Trotter WR. Investigations of thyroid antigens reacting with Hashimoto sera. Evidence for an antigen other than thyroglobulin. Lancet 1959; 1: 648-652. .
4.
Doullay F, Ruf J, Codaccioni JL, Carayon P. Prevalence of autoantibodies to thyroperoxidase in patients with various thyroid and autoimmune diseases. Autoimmunity 1991; 9: 237-244. .
5.
Fung HY, Kologlu M, Collison K, et al. Postpartum thyroid dysfunction in Mid Glamorgan. Br Med J (Clin Res Ed) 1988; 296: 241-244. .
6.
Yokoyama N, Tamog A, Klee GG. Thyroid peroxidase and thyroid microsomal autoantibodies. J Clin Endocrinol Metab 1998; 68: 766-773. .
7.
Kasagi K, Kousaka T, Higuchi K, et al. Clinical significance of measurements of antithyroid antibodies in the diagnosis of Hashimoto's thyroiditis: comparison with histological findings. Thyroid 1996; 6: 445-450. .
8.
Hollowell JG, Staehling NW, Flanders WD, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab 2002; 87: 489-499. .
9.
Prummel MF, Wiersinga WM. Thyroid peroxidase autoantibodies in euthyroid subjects. Best Pract Res Clin Endocrinol Metab 2005; 19: 1-15. .
10.
Szabolcs I, Bernard W, Horster FA. Thyroid autoantibodies in hospitalized chronic geriatric patients: prevalence, effects of age, nonthyroidal clinical state, and thyroid function. J Am Geriatr Soc 1995; 43: 670-673. .
11.
Mariotti S, Sansoni P, Barbesino G, et al. Thyroid and other organ-specific autoantibodies in healthy centenarians. Lancet 1992; 339: 1506-1508. .
12.
Vanderpump MP, Tunbridge WM, French JM, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Whickham Survey. Clin Endocrinol (Oxf) 1995; 43: 55-68. .
13.
Stankowiak-Kulpa H, Sowiński J. Kliniczne znaczenie miana autoprzeciwciał anti-TPO w diagnozowaniu chorób tarczycy. Nowiny Lekarskie 2000; 69: 606-611. .
14.
Kordonouri O, Hartmann R, Deiss D, et al. Natural course of autoimmune thyroiditis in type 1 diabetes: association with gender, age, diabetes duration, and puberty. Arch Dis Child 2005; 90: 411-414. .
15.
Punzi L, Betterle C. Chronic autoimmune thyroiditis and rheumatic manifestations. Joint Bone Spine 2004; 71: 275-283. .
17.
Gietka-Czernel M, Jastrzębska H. Rozpoznawanie i leczenie chorób tarczycy. Ośrodek Informacji Naukowej Polfa, Warszawa 2002. .
18.
Gilbert JA, Gianoukakis AG, Salehi S, et al. Monoclonal pathogenic antibodies to the thyroid-stimulating hormone receptor in Graves’ disease with potent thyroid-stimulating activity but differential blocking activity activate multiple signaling pathways. J Immunol 2006; 176: 5084-5092. .
19.
Quadbeck B, Hoermann R, Hahn S, et al. Binding, stimulating and blocking TSH receptor antibodies to the thyrotropin receptor as predictors of relapse of Graves’ disease after withdrawal of antithyroid treatment. Horm Metab Res 2005; 37: 745-750 .
20.
Eckstein AK, Plicht M, Lax H, et al. Thyrotropin receptor autoantibodies are independent risk factors for Graves’ ophthalmopathy and help to predict severity and outcome of the disease. J Clin Endocrinol Metab 2006; 91: 3464-3470. .
21.
Yoshida A, Hisatome I, Taniguchi S, et al. Pendrin is a novel autoantigen recognized by patients with autoimmune thyroid diseases. J Clin Endocrinol Metab 2009; 94: 442-448. .
22.
Levy O, De la Vieja A, Carrasco N. The Na+/I-symporter (NIS): recent advances. Bioenerg Biomembr 1998; 30: 195-206. .
23.
Zöphel K, Grüning T, Wunderlich G, et al. Clinical value of a bispecific antibody binding to thyroglobulin and thyroperoxidase (TGPO-aAb) in various thyroid diseases. Autoimmunity 1999; 29: 257-262. .
24.
Hansen BU, Ericsson UB, Henricsson V, et al. Autoimmune thyroiditis and primary Sjögren's syndrome: clinical and laboratory evidence of the coexistence of the two diseases. Clin Exp Rheumatol 1991; 9: 137-141. .
25.
Punzi L, Ostuni PA, Betterle C, et al. Thyroid gland disorders in primary Sjögren's syndrome. Rev Rhum Engl Ed 1996; 63: 809-814. .
26.
D'Arbonneau F, Ansart S, Le Berre R, et al. Thyroid dysfunction in primary Sjögren's syndrome: a long-term followup study. Arthritis Rheum 2003; 49: 804-809. .
27.
Shiroky JB, Cohen M, Ballachey ML, et al. Thyroid dysfunction in rheumatoid arthritis: a controlled prospective survey. Ann Rheum Dis 1993; 52: 454-456. .
28.
Atzeni F, Doria A, Ghirardello A, et al. Anti-thyroid antibodies and thyroid dysfunction in rheumatoid arthritis: prevalence and clinical value. Autoimmunity 2008; 111-115.
29.
Innocencio RM, Romaldini JH, Ward LS. Thyroid autoantibodies in autoimmune diseases. Medicina (B Aires) 2004; 64: 227-230. .
30.
Yavasoglu I, Senturk T, Coskun A, et al. Rheumatoid arthritis and anti-thyroid antibodies. Autoimmunity 2009; 42: 168-169. .
31.
Pyne D, Isenberg DA. Autoimmune thyroid disease in systemic lupus erythematosus. Ann Rheum Dis 2002; 61: 70-72. .
32.
Antonelli A, Fallahi P, Mosca M, et al. Prevalence of thyroid dysfunctions in systemic lupus erythematosus. Metabolism 2010; 59: 896-900. .
33.
Mader R, Mishail S, Adawi M, et al. Thyroid dysfunction in patients with systemic lupus erythematosus (SLE): relation to disease activity. Clin Rheumatol 2007; 26: 1891-1894. .
34.
De Keyser L, Narhi DC, Furst DE, et al. Thyroid dysfunction in a prospectively followed series of patients with progressive systemic sclerosis. J Endocrinol Invest 1990; 13: 161-169. .
35.
Marasini B, Ferrari PA, Solaro N, et al. Thyroid dysfunction in women with systemic sclerosis. Ann N Y Acad Sci 2007; 1108: 305-311. .
36.
Lee HJ, Kim MY, Ha SJ, et al. Two cases of morphea associated with Hashimoto's thyroiditis. Acta Derm Venereol 2002; 82: 58-59. .
37.
Antonelli A, Delle Sedie A, Fallahi P, et al. High prevalence of thyroid autoimmunity and hypothyroidism in patients with psoriatic arthritis. J Rheumatol 2006; 33: 2026-2028. .
38.
Gul U, Gonul M, Kaya I, Aslan E. Autoimmune thyroid disorders in patients with psoriasis. Eur J Dermatol 2009; 19: 221-223. .
39.
de Carvalho JF, Caleiro MT Primary antiphospholipid syndrome and thyroid involvement. J Clin Rheumatol 2010; 16: 164-167. .
40.
Mavragani CP, Danielides S, Zintzaras E, et al. Antithyroid antibodies in antiphospholipid syndrome: prevalence and clinical associations. Lupus 2009; 18: 1096-1099. .
41.
Dent RG, Edwards OM. Autoimmune thyroid disease and the polymyalgia rheumatica-giant cell arteritis syndrome. Clin Endocrinol (Oxf) 1978; 9: 215-219. .
42.
Myklebust G, Gran JT A prospective study of 287 patients with polymyalgia rheumatica and temporal arteritis: clinical and laboratory manifestations at onset of disease and at the time of diagnosis. Br J Rheumatol 1996; 35: 1161-1168. .
43.
Juchet H, Labarthe MP, Ollier S, et al. Prevalence of hypothyroidism and hyperthyroidism in temporal arteritis and rhizomelic pseudopolyarthritis. A controlled study of 104 cases. Rev Rhum Ed Fr 1993; 60: 493-498. .
44.
White SW, Tesar JT. Dermatomyositis and dermatitis herpetiformis. Arch Dermatol 1982; 118: 599-601. .
45.
Bianchi DW, Zickwolf GK, Weil GJ, et al. Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum. Proc Natl Acad Sci U S A 1996; 93: 705-708. .
46.
Adams KM, Nelson JL. Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy Immunol Invest 2008; 37: 631-644. .
47.
Adams KM, Nelson JL Microchimerism: an investigative frontier in autoimmunity and transplantation. JAMA 2004; 291: 1127-1131. .
48.
Cockrill T, del Junco DJ, Arnett FC, et al. Separate influences of birth order and gravidity/parity on the development of systemic sclerosis. Arthritis Care Res (Hoboken) 2010; 62: 418-424. .
49.
Walsh JP, Bremner AP, Bulsara MK, et al. Parity and the risk of autoimmune thyroid disease: a community-based study. J Clin Endocrinol Metab 2005; 90: 5309-5312. .
50.
Badenhoop K. Intrathyroidal microchimerism in Graves’ disease or Hashimoto’s thyroiditis: regulation of tolerance or alloimmunity by fetal-maternal immune interactions? Eur J Endocrinol 2004; 150: 421-423. .
51.
Gebe JA, Swanson E, Kwok WW. HLA class II peptide-binding and autoimmunity. Tissue Antigens 2002; 59: 78-87. .
52.
Vaidya B, Pearce S. The emerging role of the CTLA-4 gene in autoimmune endocrinopathies. Eur J Endocrinol 2004; 150: 619-626. .
53.
Velaga MR, Wilson V, Jennings CE, et al. The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves’ disease. J Clin Endocrinol Metab 2004; 89: 5862-5865. .
54.
Ostanek M, Ciechanowicz A. Czynniki genetyczne w patogenezie reumatoidalnego zapalenia stawów. Reumatologia 2009; 47: 143-150.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
RELATED ARTICLE
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
