REVIEW PAPER
Mixed connective tissue disease: 40 years of history
Online publication date: 2011-09-27
Reumatologia 2011;49(5):366-371
KEYWORDS
ABSTRACT
The history of mixed connective tissue disease (MCTD) started 40 years ago as a result of long-term observation of patients with features resembling systemic lupus erythematosus (SLE), scleroderma and poly- or dermatomyositis. A high titre of anti-extractable nuclear antigen antibodies (anti-ENA) in these patients was also revealed. This paper presents formation of views on clinical aspects of MCTD, development of diagnostic methods identifying antigens involved in disease initiation and modern technique appliance in defining pathogenic mechanisms (Table I). Looking at the growing knowledge on MCTD we can follow 40 years of medicine progress.
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