Current issue
Archive
Online first
About the Journal
Editorial Office
Editorial Board
Publisher
Editorial Policies
Ethical standards and procedures
Abstracting and indexing
Reviewers
Honorary Reviewers
Subscription
Contact
Most read articles
Instructions for authors
Article processing charge (APC)
Books and Events
Books
Events
ORIGINAL PAPER
Pulmonary function tests and diffusing capacity in patients with systemic sclerosis
Online publication date: 2010-12-20
Reumatologia 2010;48(6):402-405
KEYWORDS
ABSTRACT
Background: Connective tissue disease effect many organs. In the respiratory system they may cause numerous symptoms as: dry cough, dyspnea and fatigue.
Aim of the study: The purpose of this study was to evaluate changes in pulmonary functional tests in course of the systemic sclerosis.
Material and methods: Study was conducted in the group of 39 patients with systemic sclerosis. Patients were observed in the period from 2 to 44 months. In this time pulmonary functional tests and lung diffusion capacity were measured at least twice. The following indicies were evaluated: DLCOc, FVC, FEV1 and TLC.
Results: The most significant changes in the course of systemic sclerosis were observed in DLCOc. In most of studied patients this parameter was already depressed at the beginning of the study and significantly changed during the observation.
Conclusions: Repetitive measurements of DLCOc allows to evaluate the advance and progress of systemic sclerosis. The other evaluated parameters are less relevant clinically.
Aim of the study: The purpose of this study was to evaluate changes in pulmonary functional tests in course of the systemic sclerosis.
Material and methods: Study was conducted in the group of 39 patients with systemic sclerosis. Patients were observed in the period from 2 to 44 months. In this time pulmonary functional tests and lung diffusion capacity were measured at least twice. The following indicies were evaluated: DLCOc, FVC, FEV1 and TLC.
Results: The most significant changes in the course of systemic sclerosis were observed in DLCOc. In most of studied patients this parameter was already depressed at the beginning of the study and significantly changed during the observation.
Conclusions: Repetitive measurements of DLCOc allows to evaluate the advance and progress of systemic sclerosis. The other evaluated parameters are less relevant clinically.
REFERENCES (13)
1.
Rzymkowska M. Zmiany śródmiąższowe w chorobach reumatycznych. Przew Lek 2007; 1: 30-33. .
2.
Wisłowska M, Dereń D. Powikłania płucne w chorobach reumatoidalnych obserwowane w oddziale reumatologicznym CSK MSWiA. Ogólnopolskie sympozjum naukowo-szkoleniowe: Powikłania płucne w chorobach reumatycznych. Białowieża 2004. Materiały sympozjum, 69-70. .
3.
Steen VD, Medsger TA. Changes in causes of death in systemic sclerosis, 1972-2002. Ann Rheum Dis 2007; 66: 940-944. .
4.
MacIntyre N, Crapo RO, Viegi G, et al. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur Respir J 2005; 26: 720-735. .
5.
Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J 2005; 26: 319-338. 6. Crapo RO, Morris AH, Clayton PD, Nixon CR. Lung volumes in healthy nonsmoking adults. Bull Eur Physiopathol Respir 1982; 18: 419-425. .
6.
Abramson MJ, Barnett AJ, Littlejohn GO, et al. Lung function abnormalities and decline of spirometry in scleroderma: an overrated danger? Postgrad Med J 1991; 67: 632-637. .
7.
Steven D, Nathan MD. Connective Tissue Disease and Interstitial Lung Disease Pulmonary. Medscape Pulmonary Medicine 2007. .
8.
Gilson M, Zerkak D, Wipff J, et al. Prognostic factors for lung function in systemic sclerosis: prospective study of 105 cases. Eur Respir J 2010; 35: 112-117. .
9.
Wells AU, Du Bois RM, Nicholson AG. Pulmonary Fibrosis in Connective Tissue Disease. In: Idiopathic Pulmonary Fibrosis. Lynch JP (ed). Medical Marcel Dekker, INC New York, Basel 2004. .
10.
Mogulkoc N, Brutsche MH, Bishop P, et al. Pulmonary function in idiopathic pulmonary fibrosis and raferral for lung transplantation. Am J Respir Crit Care Med 2001; 164: 103-108. .
11.
Erbes R, Schaberg T, Loddenkemper R. Lung function tests in patients with idiopathic pulmonary fibrosis. Chest 1997; 111: 51-57. .
12.
Martinez FJ. Pulmonary function testing. In: Pulmonary disease diagnosis and therapy: a practical approach, Khan MG, Lynch JP (eds). Williams & Wilkins. Baltimore 1997; 107-141 .
13.
Martinez FJ, Lynch JP. Role of Physiological Assessment in Usual Interstitial Pneumonia. In: Idiopathic Pulmonary Fibrosis. Lynch JP (ed). Medical Marcel Dekker, INC New York, Basel 2004.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
RELATED ARTICLE
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
