There are those who support and others who refute the use of medical eponyms. Clarified are the use of the terms eponyms and medical eponyms. We proposed the redesign of a more specific definition for a medical eponym. Therefore, a medical eponym in clinical medicine is defined as a honorific term bestowed to an individual who identified or discovered, a disease, sign, symptom, syndrome, test, finding, anatomical part, or designed a device, procedure, view, treatment, classification, prediction rule, principle, or algorithm. Thus medical eponyms include those aspects which involve patient care or applications of care. Further discussed and clarified are misconceptions regarding the use of medical eponyms, distinguishing features of other types of “onyms”, and supporting and opposing views regarding their retention and disbarment. Recognized is the importance that medical eponyms be carefully studied using an evidence-based approach before they are abandoned.