Rituximab-induced neutropenia in a patient with inflammatory myopathy and systemic sclerosis overlap disease
Data nadesłania: 10-12-2015
Data akceptacji: 31-01-2016
Data publikacji online: 24-03-2016
Data publikacji: 29-02-2016
Reumatologia 2016;54(1):35-37
Rituximab (RTX) is a monoclonal chimeric antibody directed against the CD20 antigen of B lymphocytes. Late onset neutropenia (LON) is a recognised complication of rituximab usually occurring 4 weeks after the last dose and is reported in both haematological and rheumatological conditions. However, it has never been described in a patient with myositis and systemic sclerosis overlap disease.We describe a case of LON in a 54-year-old man who was diagnosed with myositis and then systemic sclerosis overlap disease. It resolved within 7 days, and the patient did not suffer neutropenic sepsis or any other complications. We propose similar mechanisms for LON as described in other conditions and routine blood monitoring in such patients.
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