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5/2012 vol. 50
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PRACA PRZEGLĄDOWA
Rola endotelialnych komórek progenitorowych i potencjału redoks w neowaskularyzacji błony maziowej stawu
Przemysław Rzodkiewicz
,
 
Michał Gajewski
,
 
Sławomir Maśliński
,
 
Elżbieta Wojtecka-Łukasik
 
 
 
Więcej
Ukryj
 
Data publikacji online: 06-11-2012
 
 
Reumatologia 2012;50(5):432-437
DOI: https://doi.org/10.5114/reum.2012.31406
 
 
Artykuł (PDF)
Referencje (41)
 
SŁOWA KLUCZOWE
neowaskularyzacja błony maziowej
NADPH oksydaza
redoks
endotelialne progenitorowe komórki macierzyste
 
STRESZCZENIE
Zwiększona neowaskularyzacja błony maziowej jest jednym z istotnych elementów patomechanizmu rozwoju reumatoidalnego zapalenia stawów (RZS). Jednym z czynników mających znaczenie w przebiegu tego procesu jest produkcja wolnych rodników tlenowych, które wpływają zarówno na proces neowaskularyzacji, jak i na metabolizm endotelialnych komórek progenitorowych. Zaburzenia związane z produkcją wolnych rodników tlenowych w przebiegu zapalenia mogą być więc nie tylko bezpośrednią przyczyną uszkodzeń obserwowanych w przebiegu RZS, lecz także czynnikiem wpływającym na przebieg choroby. W niniejszej publikacji przedstawiono stan aktualnej wiedzy na temat procesu neowaskularyzacji, ze szczególnym omówieniem znaczenia potencjału redoks.
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