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6/2015 vol. 53
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REVIEW PAPER
Syndromes with chronic non-bacterial osteomyelitis in the spine
Łukasz Kubaszewski
,
 
Piotr Wojdasiewicz
,
 
Marcin Rożek
,
 
Iwona E. Słowińska
,
 
Katarzyna Romanowska-Próchnicka
,
 
Radosław Słowiński
,
 
Łukasz A. Poniatowski
,
 
Robert Gasik
 
 
 
More details
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Submission date: 2015-10-31
 
 
Final revision date: 2015-12-13
 
 
Acceptance date: 2016-01-08
 
 
Online publication date: 2016-02-11
 
 
Publication date: 2016-02-15
 
 
Reumatologia 2015;53(6):328-336
DOI: https://doi.org/10.5114/reum.2015.57639
 
 
Article (PDF)
References (61)
 
KEYWORDS
osteomyelitis
SAPHO syndrome
CRMO
non-bacterial inflammation
 
TOPICS
Other bone diseases
 
ABSTRACT
Chronic non-bacterial osteomyelitis (CNO) has been known for over of 40 years. It is an underrecognized entity due to the low number of described cases and poor propagation awareness of the problem. Chronic non-bacterial osteomyelitis is usually confused with infectious spondylodiscitis or malignant lesions, both primary and metastatic. Failing to consider CNO as one of possible lesions of the spine among an array of differential diagnoses may lead to a prolonged ineffective treatment increasing treatment-related morbidity. In this paper the authors describe these two syndromes, with a possible autoimmune background – chronic recurrent multifocal osteomyelitis (CRMO) and SAPHO syndrome – that include CNO being among the manifestations. The authors present the spinal symptomatology of CNO for both syndromes published so far to help spine clinicians organize the information for better usage in everyday clinical practice.
 
REFERENCES (61)
1.
Takigawa T, Tanaka M, Nakanishi K, et al. SAPHO syndrome associated spondylitis. Eur Spine J 2008; 17: 1391-1397.
Google Scholar
 
 
2.
Kotilainen P, Gullichsen RE, Saario R, et al. Aseptic spondylitis as the initial manifestation of the SAPHO syndrome. Eur Spine J 1997; 6: 327-329.
Google Scholar
 
 
3.
Giedion A, Holthusen W, Masel LF, Vischer D. Subacute and chronic “symmetrical” osteomyelitis. Ann Radiol (Paris) 1972; 15: 329-342.
Google Scholar
 
 
4.
Sasaki T. A case of osteomyelitis of the bilateral clavicles associated with pustulosis palmaris et plantaris. Rinsho Seikeigeka 1967; 2: 333-337.
Google Scholar
 
 
5.
Ferguson PJ, Sandu M. Current understanding of the pathogenesis and management of chronic recurrent multifocal osteomyelitis. Curr Rheumatol Rep 2012; 14: 130-141.
Google Scholar
 
 
6.
Hofmann SR, Roesen-Wolff A, Hahn G, Hedrich CM. Update: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO). Int J Rheumatol 2012; 2012: 310206.
Google Scholar
 
 
7.
Toussirot E, Dupond JL, Wendling D. Spondylodiscitis in SAPHO syndrome. A series of eight cases. Ann Rheum Dis 1997; 56: 52-58.
Google Scholar
 
 
8.
Zimmermann-Górska I, Puszczewicz M, Pietrzak-Kaczmarek H, Kołczewska A. Osteitis as a symptom of SAPHO syndrome. Pol Arch Med Wewn 2003; 110: 755-758.
Google Scholar
 
 
9.
Chamot AM, Benhamou CL, Kahn MF, et al. Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases. Rev Rhum Mal Osteoartic 1987; 54: 187-196.
Google Scholar
 
 
10.
Hayem G, Bouchaud-Chabot A, Benali K, et al. SAPHO syndrome: a long-term follow-up study of 120 cases. Semin Arthritis Rheum 1999; 29: 159-171.
Google Scholar
 
 
11.
Girschick HJ, Mornet E, Beer M, et al. Chronic multifocal non-bacterial osteomyelitis in hypophosphatasia mimicking malignancy. BMC Pediatr 2007; 7: 3.
Google Scholar
 
 
12.
Baba H, Uchida K, Wada M, et al. Vertebral lesions associated with palmoplantar pustulosis. Int Orthop 1997; 21: 19-24.
Google Scholar
 
 
13.
Silva PC, Oliveira EF, Goldenzon AV, et al. Challenges in diagnosis and treatment of a case of SAPHO syndrome in. Ann Bras Dermatol 2011; 86 (4 Suppl 1): S46-49.
Google Scholar
 
 
14.
Girschick HJ, Raab P, Surbaum S, et al. Chronic non-bacterial osteomyelitis in children. Ann Rheum Dis 2005; 64: 279-285.
Google Scholar
 
 
15.
Kahn MF, Chamot AM. SAPHO Syndrome. Rheum Dis Clin N Am 1992; 18: 225-246.
Google Scholar
 
 
16.
Simm PJ, Allen RC, Zacharin MR. Bisphosphonate treatment in chronic recurrent multifocal osteomyelitis. J Pediatr 2008; 152: 571-575.
Google Scholar
 
 
17.
Bjorksten B, Boquist L. Histopathological aspects of chronic recurrent multifocal osteomyelitis. J Bone Joint Surg 1980; 62: 376-380.
Google Scholar
 
 
18.
Roderick MR, Ramanan AV. Chronic recurrent multifocal osteomyelitis. Adv Exp Med Biol 2013; 764: 99-107.
Google Scholar
 
 
19.
Huber AM, Lam P-Y, Duffy CM, et al. Chronic recurrent multifocal osteomyelitis: clinical outcomes after more than five years of follow-up. J Pediatr 2002; 141: 198-203.
Google Scholar
 
 
20.
Scully C, Hodgson T, Lachmann H. Auto-inflammatory syndromes and oral health. Oral Dis 2008; 14: 690-699.
Google Scholar
 
 
21.
Insalaco A, Bozzola E, Campana A, et al. Chronic recurrent multifocal osteomyelitis: 17 case reports and literature review. Pediatric Rheumatology Online Journal 2008; 6 (Suppl 1): P188. doi:10.1186/1546-0096-6-S1-P188.
CrossRef
 
Google Scholar
 
 
22.
El-Shanti HI, Ferguson PJ. Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res 2007; 462: 11-19.
Google Scholar
 
 
23.
Schultz C, Holterhus PM, Seidel A, et al. Chronic recurrent multifocal osteomyelitis in children. Pediatr Infect Dis J 1999; 18: 1008-1013.
Google Scholar
 
 
24.
Quon JS, Dzus AK, Leswick DA. Case study: chronic recurrent multifocal osteomyelitis in the femoral diaphysis of a young female. Case Rep Radiol 2012; 2012: 515761.
Google Scholar
 
 
25.
Monsour PA, Dalton JB. Chronic recurrent multifocal osteomyelitis involving the mandible: case reports and review of the literature. Dentomaxillofac Radiol 2010; 39: 184-190.
Google Scholar
 
 
26.
Deogaonkar K, Ghandour A, Jones A, et al. Chronic recurrent multifocal osteomyelitis presenting as acute scoliosis: a case report and review of literature. Eur Spine J 2008; 17 Suppl 2: S248-252.
Google Scholar
 
 
27.
Haque SA, Shad A, Ozdemirli M, et al. A thirteen year old female with primary T-cell rich B-cell lymphoma of bone masquerading as chronic recurrent multifocal osteomyelitis. Pediatr Rep 2009; 1: e3.
Google Scholar
 
 
28.
King SM, Laxer RM, Manson D, Gold R. Chronic recurrent multifocal osteomyelitis: a noninfectious inflammatory process. Pediatr Infect Dis J 1987; 6: 907-911.
Google Scholar
 
 
29.
Khanna G, Sato TS, Ferguson P. Imaging of chronic recurrent multifocal osteomyelitis. Radiographics 2009; 29: 1159-1177.
Google Scholar
 
 
30.
Tsitsami E, Dermentzoglou V, Moschovi M, Chrousos GP. Chronic recurrent multifocal osteomyelitis with concomitant features of juvenile idiopathic arthritis. Case Rep Rheumatol 2011; 2011: 210795.
Google Scholar
 
 
31.
Oberc A, Sułko J. Chronic recurrent multifocal osteomyelitis (CRMO) in children –single-centre clinical observations and experience. Ortop Traumatol Rehabil 2014; 16: 297-305.
Google Scholar
 
 
32.
Baulot E, Bouillien D, Giroux EA, Grammont PM. Chronic recurrent multifocal osteomyelitis causing spinal cord compression. Eur Spine J 1998; 7: 340-343.
Google Scholar
 
 
33.
Aksentijevich I, Masters SL, Ferguson PJ, et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med 2009; 360: 2426-2437.
Google Scholar
 
 
34.
Schilling F, Fedlmeier M, Eckardt A, Kessler S. Vertebral manifestation of chronic recurrent multifocal osteomyelitis (CRMO). Rofo 2002; 174: 1236-1242.
Google Scholar
 
 
35.
Brown T, Wilkinson RH. Chronic recurrent multifocal osteomyelitis. Radiology 1988; 166: 493-496.
Google Scholar
 
 
36.
von Kalle T, Heim N, Hospach T, et al. Typical patterns of bone involvement in whole-body MRI of patients with chronic recurrent multifocal osteomyelitis (CRMO). Rofo 2013; 185: 655-661.
Google Scholar
 
 
37.
Gedouin JE, Violas P, Chapuis M, Bracq H. Stiff painful spine in an 11-year-old girl with SAPHO syndrome. Rev Chir Orthop Reparatrice Appar Mot 2001; 87: 830-834.
Google Scholar
 
 
38.
Buck FM, Treumann TC, Winiker H, Strobel K. Chronic recurrent multifocal osteomyelitis (CRMO) with symmetric involvement of both femora: X-ray, bone scintigram, and MR imaging findings in one case. J Magnetic Resonance Imaging 2007; 26: 422-426.
Google Scholar
 
 
39.
Miettunen PM, Wei X, Kaura D, et al. Dramatic pain relief and resolution of bone inflammation following pamidronate in 9 pediatric patients with persistent chronic recurrent multifocal osteomyelitis (CRMO). Pediatr Rheumatol Online J 2009; 7: 2. doi: 10.1186/1546-0096-7-2.
CrossRef
 
Google Scholar
 
 
40.
Marangoni RG, Halpern AS. Chronic recurrent multifocal osteomyelitis primarily affecting the spine treated with anti-TNF therapy. Spine (Phila Pa 1976) 2010; 35: E253-256.
Google Scholar
 
 
41.
Gleeson H, Wiltshire E, Briody J, et al. Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. J Rheumatol 2008; 35: 707-712.
Google Scholar
 
 
42.
Kahn MF, Khan MA. The SAPHO syndrome. Baillieres Clin Rheum 1994; 8: 333-362.
Google Scholar
 
 
43.
Maugars Y, Berthelot JM, Ducloux JM, Prost A. SAPHO syndrome: a follow up study of 19 cases with special emphasis on enthesis involvement. J Rheumatol 1995; 22: 2135-2141.
Google Scholar
 
 
44.
Kahn MF, Bouvier M, Palazzo E, et al. Sternoclavicular pustulotic osteitis (SAPHO). 20-year interval between skin and bone lesions. J Rheumatol 1991; 18: 1104-1108.
Google Scholar
 
 
45.
Edlund E, Johnsson U, Lidgren L, et al. Palmoplantar pustulosis and sternocostoclavicular arthro-osteitis. Ann Rheum Dis 1988; 47: 809-815.
Google Scholar
 
 
46.
Gerster JC, Lagier R, Livio JJ. Propionibacterium acnes in a spondylitis with palmoplantar pustulosis. Ann Rheum Dis 1990; 49: 337-338.
Google Scholar
 
 
47.
Kotilainen P, Merilahti-Palo R, Lehtonen OP, et al. Propionibacterium acnes isolated from sternal osteitis in a patient with SAPHO syndrome. J Rheumatol 1996; 23: 1302-1304.
Google Scholar
 
 
48.
Albert HB, Sorensen JS, Christensen BS, Manniche C. Antibiotic treatment in patients with chronic low back pain and vertebral bone edema (Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy. Eur Spine J 2013; 22: 697-707.
Google Scholar
 
 
49.
Aebi M. Is low back pain after disc herniation with Modic Type 1 changes a low-grade infection? Eur Spine J 2013; 22: 689.
Google Scholar
 
 
50.
Birkenmaier C. Should we start treating chronic low back pain with antibiotics rather than with pain medications? Korean J Pain 2013; 26: 327-335.
Google Scholar
 
 
51.
Earwaker JW, Cotten A. SAPHO: syndrome or concept? Imaging findings. Skeletal Radiol 2003; 32: 311-327.
Google Scholar
 
 
52.
Laredo JD, Vuillemin-Bodaghi V, Boutry N, et al. SAPHO Syndrome: MR Appearance of Vertebral Involvement. Radiology 2007; 242: 825-831.
Google Scholar
 
 
53.
Khan MA. Clinical features of ankylosing spondylitis. In: Rheumatology. Hochberg MC, Silman AJ, Smolen JS, et al. (eds.). Mosby, St. Louis 2003: 1161-1181.
Google Scholar
 
 
54.
Courtois C, Fallet GH, Vischer TL, Wettstein P. Erosive spondylopathy. Ann Rheum Dis 1980; 39: 462-468.
Google Scholar
 
 
55.
Mann B, Shaerf DA, Sheeraz A, et al. SAPHO syndrome presenting as widespread bony metastatic disease of unknown origin. Rheumatol Int 2012; 32: 505-507.
Google Scholar
 
 
56.
Benhamou CL, Chamot AM, Kahn MF. Synovitis-acne-pustulosis hyperostosis-osteomyelitis syndrome (Sapho). A new syndrome among the spondyloarthropathies? Clin Exp Rheumatol 1988; 6: 109-112.
Google Scholar
 
 
57.
Kaiser D, Bolt I, Hofer M, et al. Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study. Pediatr Rheumatol Online J 2015; 13: 25. doi: 10.1186/s12969-015-0023-y.
CrossRef
 
Google Scholar
 
 
58.
Heldmann F, Kiltz U, Baraliakos X, Braun J. SAPHO syndrome. Z Rheumatol 2014; 73: 729-741.
Google Scholar
 
 
59.
Takizawa Y, Murota A, Setoguchi K, Suzuki Y. Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline. Mod Rheumatol 2014; 24: 1015-1018.
Google Scholar
 
 
60.
Hampton SL, Youssef H. Successful treatment of resistant SAPHO syndrome with anti-TNF therapy. BMJ Case Rep 2013; 2013. pii: bcr2012007161. doi: 10.1136/bcr-2012-007161.
CrossRef
 
Google Scholar
 
 
61.
Maślińska M. Zespół SAPHO – opis przypadku. Reumatologia 2005; 43: 222-226.
Google Scholar
 
 
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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