CASE REPORT
The association between dermatomyositis and two different neoplasms in one patient – 4 years’ observations
Online publication date: 2010-09-21
Reumatologia 2010;48(4):271-275
KEYWORDS
ABSTRACT
The association between dermatomyositis (DM) and malignancy has been recognized for a long time. Dermatomyositis has been assessed as a paraneoplastic syndrome. The pathogenesis of this co-morbidity is poorly understood. Dermatomyositis precedes the neoplasm in some cases, in other it may occur together with the neoplasm and sometimes the neoplasm may occur first. The higher risk of the development of the neoplasm occurs during the first five years of the diagnosis of DM. Primary tumours occur in ovaries, lungs, gastrointestinal tract, breast and lymphonodes. The prognosis of the neoplasm development depends on age. The incidence of neoplasm in adults is higher than in young persons. The peak incidence occurs between the ages of 40 and 69 years. We present a case report of a 60-year-old woman with the diagnosis of DM and breast cancer and coinciding female genital tract cancers. The patient underwent the surgery and chemotherapy. The patient was observed for 11 months after completion of treatment and she was in good condition. The relapse of DM symptoms was the reason for cancer rescreening and the metastases of ovarian cancer to subcutaneous tissue of the abdomen were found.
REFERENCES (22)
1.
Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med 1975; 292: 403-407. .
2.
Provost TT, Flynn JA. Dermatomyositis. Coutaneous Medicine, BC Decker Inc., Hamilton, London 2001; 82. .
3.
Jabłońska S. Skórne zespoły paraneoplazmatyczne: rewelatory skórne nowotworów narządów wewnętrznych. Medipress Dermatol 1997; 2: 8-14. .
4.
Zhang W, Jiang SP, Huang L. Dermatomyositis and malignancy: a retrospective study of 115 cases. Eur Rev Med Pharmacol Sci 2009; 13: 77-80. .
5.
Zampieri S, Valente M, Adami M. Polymyositis, Dermatomyositis and malignancy: A further intriguing link. Autoimmun Rev 2009; 30: 1-5. .
6.
Sigurgeirsson B, Lindelöf B, Edhag O, Allander E. Risk of cancer in patients with dermatomyositis or polymyositis. A population-based study. N Engl J Med 1992; 6: 363-367. .
7.
Iftikhar I, Abdelmannan D, Daw HA. Dermatomyositis and esophageal cancer. South Med J 2006; 99: 777-779. .
8.
Chen YJ, Wu CY, Shen JL. Predicting factors of malignancy in dermatomyositis and polymyositis: a case-control study. Br J Dermatol 2001; 144: 825-831. .
9.
Wojas-Pelc A, Lipko-Godlewska S, Bogdaszewska-Czabanowska J. Zapalenie skórno-mięśniowe i wielomięśniowe próba różnicowania, leczenie – przegląd literatury. Przegląd Lekarski 2002; 59: 55-60. .
10.
Madan V, Chinoy H, Griffiths CE, Cooper RG. Defining cancer risk in dermatomyositis. Part I. Cli Exp Dermatol 2009; 34: 451-455. .
11.
Stockton D, Doherty VR, Brewster DH. Risk of cancer in patients with dermatomyositis or polymyositis, and follow-up implications: a Scottish population-based cohort study. Br J Cancer 2001; 85: 41-45. .
12.
Buchbinder R, Forbes A, Hall S, et al. Incidence of malignant disease in biopsy-proven inflammatory myopathy. A population-based cohort study. Ann Intern Med 2001; 134: 1087-1095. .
13.
Hill CL, Zhang Y, Sigurgeirsson B, et al. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet 2001; 357: 96-100. .
14.
András C, Ponyi A, Constantin T, et al. Dermatomyositis and polymyositis associated with malignancy: a 21-year retrospective study. J Rheumatol 2008; 35: 438-444. .
15.
Cox NH, Lawrence CM, Langtry JA, Ive FA. Dermatomyositis. Disease associations and an evaluation of screening investigations for malignancy. Arch Dermatol 1990; 126: 61-65. .
16.
Dourmishev LA. Dermatomyositis associated with malignancy. 12 case reports. Adv Exp Med Biol 1999; 455: 193-199. .
17.
Antiochos B, Brown I, Li Z, et al. Malignancy is associated with dermatomyositis but not polymyositis in Northen New England, USA. J Reumatol 2009; 36: 2704-2710. .
18.
Leow YH, Goh CL. Malignancy in adult dermatomyositis. Int J Dermatol 1997; 36: 904-907. .
19.
Fung WK, Chan HL, Lam WM. Amyopathic dermatomyositis in Hong Kong – association with nasopharyngeal carcinoma. Int J Dermatol 1998; 37: 659-663. .
20.
Peng JC, Sheen TS, Hsu MM. Nasopharyngeal carcinoma with dermatomyositis. Analysis of 12 cases. Arch Otolaryngol Head Neck Surg 1995; 121: 1298-1301. .
21.
Selvaag E, Thune P, Austad J. Dermatomyositis and cancer. A retrospective study. Tidsskr Nor Laegeforen 1994; 114: 2378-2380. .
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Share
RELATED ARTICLE
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
