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ORIGINAL PAPER
The effect of increasing amounts of synovial fluid isolated from patients with rheumatoid arthritis on the respiratory burst of human neutrophils
Online publication date: 2009-12-29
Reumatologia 2009;47(5):273-281
KEYWORDS
ABSTRACT
It has been proposed that the inappropriate release of oxidants and proteolytic enzymes from activated neutrophils is responsible for joint damage observed in rheumatoid arthritis (RA). The present study examines the effect of increasing concentrations of synovial fluid [SF] (0-80%) on the oxidative response of neutrophils isolated from SF of RA patients and the blood of healthy subjects. To reflect better the real conditions of the inflamed joint we used in our experiments higher concentrations of SF than was previously reported. We found that increasing the concentrations of SF has a different effect on lucigenin-dependent and luminol-dependent CL response.
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Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
| eISSN: | 2084-9834 |
| ISSN: | 0034-6233 |
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