PRACA ORYGINALNA
Wpływ wzrastających ilości płynu stawowego izolowanego od pacjentów z reumatoidalnym zapaleniem stawów na intensywność „wybuchu tlenowego” ludzkich neutrofilów
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Data publikacji online: 29-12-2009
Reumatologia 2009;47(5):273-281
SŁOWA KLUCZOWE
STRESZCZENIE
Sugeruje się, że to neutrofile poprzez wydzielane przez nie oksydanty i enzymy proteolityczne są odpowiedzialne za uszkodzenia stawów, obserwowane podczas reumatoidalnego zapalenia stawów. W niniejszej pracy neutrofile, izolowane zarówno od zdrowych dawców, jak i pacjentów chorych na reumatoidalne zapalenie stawów, eksponowano na zwiększające się stężenia płynu stawowego (0-80%). Warunki te uznano za zbliżone do warunków panujących in vivo w jamie stawu kolanowego. Wykazano, że zwiększające się stężenia płynu stawowego znacząco odmiennie wpływały na badane typy chemiluminescencji: luminolo- i lucigeninozależne.
REFERENCJE (20)
1.
Allen RC. Halide dependence of the myeloperoxidase-mediated antimicrobial system of the polymorphonuclear leukocyte in the phenomenon of electronic excitation. Biochem Biophys Res Commun 1975; 63: 675-683.
2.
Nurcombe HL, Edwards SW. Role of myeloperoxidase in intracellular and extracellular chemiluminescene of neutro-phils. Ann Rheum Dis 1989; 48: 56-62.
3.
Bender JG, Van Epps DE, Searles R, et al. Altered functions of synovial fluid granulocytes in patients with acute inflammatory arthritis: evidence for activation of neutrophils and its mediation by a factor present in synovial fluid. Inflammation 1986; 10: 443-453.
4.
Gale R, Bertouch JV, Bradley J, et al. Direct activation of neutrophil chemiluminescence by rheumatoid sera and synovial fluid. Ann Rheum Dis 1983; 42: 158-162.
5.
Robinson J, Watson F, Bucknall RC, et al. Activation of neutrophil reactive-oxidant production by synovial fluid from patients with inflammatory joint disease. Biochem J 1992; 286: 345-351.
6.
Duluray B, Badesha JS, Dieppe PA, et al. Oxidative response of polymorphonuclear leucocytes to synovial fluid from patients with rheumatoid arthritis. Ann Rheum Dis 1990; 49: 661-664.
7.
Nurcombe HL, Bucknall RC, Edwards SW. Activation of the neutrophil myeloperoxidase H2O2 system by synovial fluid isolated from patients with rheumatoid arthritis. Ann Rheum Dis 1991; 50: 237-242.
8.
Duluray B, Yea CM, Elson CJ. Inhibition of myeloperoxidase by synovial fluid and serum, Ann. Rheum Dis 1991; 50: 383-388.
9.
Bostan M, Brasoveanu LI, Livescu A, et al. Effect of synovial fluid on the respiratory burst of granulocytes in rheumatoid arthritis. J Cell Mol Med 2001; 5: 188-194.
10.
Robinson JJ, Watson F, Phelan M, et al. Activation of neutrophils by soluble and insoluble immunoglobulin aggregates from synovial fluid of patients with rheumatoid arthritis. Ann Rheum Dis 1993; 52: 347-353.
11.
Edwards SW, Hallett MB. Seeing the wood for the trees: the forgoten role of neutrophils in rheumatoid arthritis. Immunol Today 1997; 18: 320-324.
12.
Davies EV, Williams BD, Campbell AK. Synovial fluid polymorphonuclear leukocytes from patients with rheumatoid arthritis have reduced MPO and NADPH-oxidase activity. Brit J Rheum 1990; 29: 415-421.
13.
Sato H, Takahashi T, Ide H, et al. Antioxidant activity of synovial fluid, hyaluronic acid, and two subcomponents of hyaluronic acid. Arthritis Rheum 1988; 31: 63-81.
14.
Nurcombe HL, Bucknall RC, Edwards SW. Neutrophils isolated from the synovial fluid of patients with rheumatoid arthritis: priming and activation in vitro. Ann Rheum Dis 1991; 50: 147-153.
15.
Eggleton P, Wang L, Penhallow J. Differences in oxidative response of subpopulations of neutrophils from healthy subjects and patients with rheumatoid arthritis. Ann Rheum Dis 1995; 54: 916-923.
16.
Fossati G, Bucknall RC, Edwards SW. Insoluble and soluble immune complexes activate neutrophils by distinct activation mechanisms: changes in functional responses induced by priming with cytokines. Ann Rheum Dis 2002; 61: 13-19.
17.
Sugisawa H, Itou T, Ichimura Y, et al. Bovine milk enhances the oxidative burst activity of polymorphonuclear leukocytes in low concentration. J Vet Med Sci 2002; 64: 113-116.
18.
Bell AL, Magill MK, Irvine AE. Human blood and synovial fluid neutrophils cultured in vitro undergo programmed cell death which is promoted by the addition of synovial fluid. Ann Rheum Dis 1995; 54: 910-915.
19.
Savill J. Apoptosis in resolution of inflammation. J Leuko Biol 1997; 61: 375-80.
20.
Iking-Konert C, Ostendorf B, Sander O, et al. Transdif-ferentiation of polymorphonuclear neutrophils to dendritic-like cells at the site of inflammation in rheumatoid arthritis: evidence for activation by the T cells. Ann Rheum Dis 2005; 64: 1436-1442.
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