The purpose of this study was to evaluate whether the changes in blood and wound fluid cytokine levels, C-reactive protein, anti-cyclic citrullinated peptide antibodies and cartilage oligomeric matrix protein are involve in inflammatory response following total knee arthroplasty. The study population consisted of 11 patients with a primary diagnosis of RA, who underwent total knee arthroplasty under spinal anesthesia. Peripheral blood samples were collected in the operative room before surgery, preoperatively and in the recovery room at 6, 12, 24, 36 hours for all patients. The wound drainage fluid samples were collected in the same time postoperatively. Operation and recovery in all patients was uneventful. The results of our study indicate that many times greater level of cytokines in drainage fluid could evidence that the local inflammatory response to surgical trauma was predominated for the most part, during the first 36 hours postoperatively.