REVIEW PAPER
Treatment of gout in patients after organ transplantation
Submission date: 2013-01-22
Final revision date: 2013-03-29
Acceptance date: 2013-05-09
Online publication date: 2013-06-26
Publication date: 2013-06-28
Reumatologia 2013;51(3):215-220
KEYWORDS
TOPICS
ABSTRACT
The occurrence of gout in patients undergoing organ transplantation is an important problem, often causing diagnostic and therapeutic difficulties. Hyperuricemia occurs in 5–84% and gout in 1.7–28% of patients after solid organ transplantation. In organ recipients in addition to risk factors commonly occurring in the general population there are also specific risk factors for this group such as use of diuretics or immunosuppressants and very often co-existing deterioration of renal function or function impairment in a transplanted kidney. The incidence of gout attacks depends to a large extent on the immunosuppressive treatment applied in a patient and most cases occur during the use of cyclosporine. Treatment of gouty arthritis in patients after transplantation often causes many difficulties due to significant drug interactions and the coexistence of renal failure. Mycophenolate mofetil has the best safety profile in this area. Not to be neglected is also the right choice of antihypertensive drugs.
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