ARTYKUŁ PRZEGLĄDOWY/REVIEW PAPER
Excitatory amino acids and rheumatoid diseases
Excitatory amino acids and rheumatoid diseases
Online publication date: 2005-12-22
Reumatologia 2005;43(6):349-353
KEYWORDS
ABSTRACT
Excitatory amino acid (EAA), glutamate is a major neurotransmitter in the central nervous system. Its role in the periphery remains mostly unknown. Recently, EAA receptors there found on peripheral sensory terminals and dorsal root ganglion cells implicating their involvement in sensory and nociceptive transduction. The involvement of EAA mechanisms in inflammation was also suggested.
It can be speculated that the use of EAA antagonists may provide a novel alternative for pharmacological intervention in joint inflammation and pain.
Copyright: © Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie. This is an Open Access journal, all articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (https://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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