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Extrahepatic manifestations of hepatitis C virus infection
 
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Online publication date: 2010-04-08
 
 
Reumatologia 2009;47(6):364-367
 
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ABSTRACT
Hepatitis C virus (HCV) infection causes the appearance of various extrahepatic manifestations. These include cryo-globulinaemia, kidney diseases, arthropathy, \'sicca syndrome\', neurological signs and appearance of autoantibodies, as described in this article. There are no defined strategies of treatment for these manifestations – the therapy should be individualized. The first line consists of antiviral treatment, if it is not contraindicated. Antiviral therapy is based on the use of interferon and ribavirin. However, we should remember that interferon stimulates and modifies the functions of the immune system and may exacerbate the autoimmune phenomena
 
REFERENCES (25)
1.
Misiani R, Bellevita P, Fenili D, et al. Hepatitis C virus infection in patients with essential mixed cryoglobulinemia. Ann Intern Med 1992; 117: 573-577. .
 
2.
Zignego AL, Ferri C, Pileri SA, et al. For the Italian Association of the Study of Liver (AISF) Commission on Extrahepatic Manifestations of HCV infection. Extrahepatic manifestations of hepatitis C Virus infection: a general overview and guidelines for a clinical approach. Dig Liver Dis 2007; 39: 2-17. .
 
3.
Dore MP, Fattovich G, Sepulveda AR, et al. Cryoglobulinemia Related to Hepatitis C Virus Infection. Dig Dis Sci 2007; 52: 897-907. .
 
4.
Tedeschi A, Baraté C, Minola E, et al. Cryoglobulinemia. Blood Rev 2007; 21: 183-200. .
 
5.
Agnello V, De Rosa FG. Extrahepatic disease manifestations of HCV infection: some current issues. J Hepatol 2004; 40: 341-352. .
 
6.
Cacoub P, Maisonobe T, Thibault V, et al. Systemic vasculitis in patients with hepatitis C. J Rheumatol 2001; 28: 109-118. .
 
7.
Landau D-A, Saadoun D, Calabrese LH, et al. The pathophysiology of HCV induced B-cell clonal disorders. Autoimmunity Rev 2007; 6: 581-587. .
 
8.
Zuckerman E, Zuckerman T, Levine AM, et al. Hepatitis C virus infection in patients with B-cell non-Hodgkin lymphoma. Ann Intern Med 1997; 127: 423-428. .
 
9.
Daghestani L, Pomeroy C. Renal manifestations of hepatitis C infection. Am J Med 1999; 106: 347-354. .
 
10.
Martin P, Fabrizi F. Hepatitis C virus and kidney disease. J Hepatol 2008; 49: 613-624. .
 
11.
Coccoli P, Esposito P, Cianciaruso B, et al. Hepatitis C and kidney disease. Dig Liver Dis 2007; 39 (Suppl.1): 83-85. .
 
12.
Barkhuizen A, Rosen HR, Wolf S, et al. Musculoskeletal pain and fatigue are associated with chronic hepatitis C: A report of 239 hepatology clinic patients. Am J Gastroenterol 1999; 94: 1355-1360. .
 
13.
Buskila D. Hepatitis C-associated arthritis. Curr Opin Rheumatol 2000; 12: 295-299. .
 
14.
Mariette X. Hepatitis C virus, artheritides, and arthromyalgia (Editorial). Joint Bone Spine 2003; 70: 246-247. .
 
15.
Ramos-Casals M, Garcia-Carrasco M, Zerón MP, et al. Viral etiopathogenesis of Sjögren’s syndrome: role of the hepatitis C virus. Autoimmunity Reviews 2002; 1: 238-243. .
 
16.
Ramos-Casals M, Garcia-Carrasco M, Cervera R, et al. Is hepatitis C virus a sialotropic virus? Am J Pathol 2001; 159: 1593-1594. .
 
17.
Madaliński K, Godzik P, Zimmermann-Górska I, et al. Anty-HCV oraz HCV-RNA u chorych z pierwotnym zespołem Sjögrena. Przegl Epidemiol 2009; 63: 299-304. .
 
18.
Huang MJ, Wu SS, Liaw YF. Thyroid abnormalities in patients with chronic viral hepatitis. Hepatology 1994; 20: 1651-1652. .
 
19.
Forton DM, Allsop JM, Main J, et al. Evidence for a cerebral effect of the hepatitis C virus. Lancet 2001; 358: 38-39. .
 
20.
Radkowski M, Wilkinson J, Nowicki M, et al. Search of hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: Evidence of replication. J Virol, 2002; 76: 600-608. .
 
21.
Joshi S, Kuczynski M, Heathcote EJ. Symptomatic and virological response to antiviral therapy in hepatitis C associated with extrahepatic complications of cryoglobulimia. Dig Dis Sci 2007; 52: 2410-2417. .
 
22.
Cacoub P, Ratziu V, Myers RP, et al. Impact of treatment on extrahepatic manifestations in patients with chronic hepatitis. J Hepatol 2002; 36: 812-818. .
 
23.
Guillevin L, Pagnoux C. Indication for plasma exchange for systemic necrotizing vasculidities. Transfus Apher Sci 2007; 36: 179-185. .
 
24.
Visentini M, Granata M, Veneziano ML, et al. Efficacy of low-dose rituximab for mixed cryoglobulinemia. Clinical Immunology 2007; 125: 30-33. .
 
25.
Ferri G, Clodovedo I, Pietrogrande P, et al. Low-antigen-content diet in the treatment of patients with mixed cryoglobulinemia. Am J Med 1989; 87: 519-524.
 
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