In 26 HCV infected patients with arthralgia, prevalence of anti-fodrin antibodies and anti-filaggrin antibodies was estimated – in comparison with other immunological markers (ANA, cryoglobulinaemia, CCI, RF, anti-SSA) and clinical symptoms. Anti-filaggrin antibodies were found in one case, anti-fodrin antibodies in 2 cases. Cryoglobulins, CCI and RF were frequent in the assessed group. Most patients had different symptoms simultaneously. In HCV infected patients arthralgias have a different mechanism than in rheumatoid arthritis – although RF IgM is frequently found. Patients have often cryoglobulinaemia and complexaemia. Anti-SSA, anti-SSB and anti-fodrin antibodies are rare in HCV-infected patients. Sicca syndrome in HCV infection is frequent, but the aetiology is probably different than in classic Sjögren’s syndrome.